Abstract: ［Abstract］〓Objective〖HTSS〗〓To observed the clinical effect of argatroban on early acute cerebral infarction patients treated with alteplase thrombolytic therapy, and to explore the best drug and treatment after thrombolytic therapy for acute cerebral infarction patients.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty early acute cerebral infarction patients treated with alteplase thrombolysis were randomly divided into control group and experimental group, 30 cases in each group. The control group received edaravone by intravenous drip, 30 mg/time, 2 times/d for 7 days. The experimental group received  argatroban by intravenous drip on the basis of the control group, 60 mg/d for the first 2 days and 20 mg/d for the next 5 days. Before treatment, 7 and 30 days after treatment, the linical therapeutic effect of the two groups was evaluated by “Evaluating Criteria for the Clinical Efficacy of Stroke Patients”, the degree of neurological impairment was assessed according to the National Institutes of Health Stroke Scale(NIHSS), the Daily life quality was assessed by Activity of Daily Living Scale(ADL), the state of cerebrovascular recanalization was evaluated by transcranial Doppler ultrasound.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After treatment, the NIHSS score of the two groups showed decreased gradually trend, the ADL score and blood flow velocity of middle cerebral artery showed increased gradually trend, the NIHSS score of the experimental group was lower than that of the control group, the ADL score and blood flow velocity of middle cerebral artery were higher than that of the control group. There were statistical significance in the differences among intergroup, time point, intergrouptime point interaction（P＜0.05）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Comparing with edaravone, the combination treament of argatroban and edaravone  for early acute cerebral infarction patients treated with alteplase thrombolysis could effectively reduce the neurological impairment degree, improve the daily life quality and cerebral vascular recanalization, increase therapeutic effect.

Key words: brain infarction； argatroban, edaravone