Abstract: [
Abstract ] Objective Toexploretheeffectsofbutylphthalidecombinedwithedaravoneon
blood-brainbarrierpermeabilityandoccludinexpressionsincortexoffocalcerebralinfarctionin
rats.Methods Sixtysprague-dawleymaleratswererandomlydividedintofourgroups : control
group , modelgroup , butylphthalidegroupandbutylphthalidecombinedwithedaravonegroup ,
with15ratsineachgroup.Themodelwasestablishedbasedontheprincipleofphotochemical
initiationofthrombosis.At72hafterinjury , evansblueextravsationmethodwasusedtodetect
theblood-brain barrierpermeability.Immunohistochemistryand western blot wereusedto
examinethecortexoccludinexpressionaroundtheinfarctionarea.Results Comparedwiththe
controlgroup , theblood-brainbarrierpermeabilitiesinthemodelgroup
, butylphthalidegroup
andthebutylphthalidecombined withedaravonegroup wereincreasedsignificantly.Andthe
occludinexpressionsaroudtheinfarction wereupregulatedsignificantly.Compared withthe
modelgroup : evans blueextravsationsin cortexin the butylphthalide group andin the butylphthalidecombined withedaravonegroup weredecreased , andtheoccludinexpressions
aroudtheinfarctionareawereincreased.Comparedwiththethebutylphthalidegroup : evansblue
extravsationincortexinthebutylphthalidecombinedwithedaravonegroupwasdecreased , and
theoccludinexpressionaroudtheinfarction wasincreased.Conclusion Butylphthalidecould
protectthebolld-brainbarrier , andincreasetheexpressionofoccludin.Theeffectwas more
obviousbyusingthecombinationofbutylphthalideandedaravone.

Key words: braininfarction , blood-brainbarrier , butylphthalide , edaravone