Abstract: Objective To explore serum levels of brain natriuretic peptide(BNP),endothelin-1 (ET-1)and nitrogen monoxide(NO)in rats after acute myocardial infarction(AMI)and to observe their correlation. Methods Eighty male Wister rats were randomly divided into two groups:sham group(n =40),AMI group(n = 40). The serum concentrations of BNP,ET-1 and NO were measured at different time(6h,12h,24h,3d,7d and 30d)to compare the difference between two groups,and their correlation were analyzed. Results There were significant difference in the serum levels of BNP,ET-1 and NO between AMI group and sham group(P ﹤ 0. 01). For different groups,there were significant differences in the serum levels of BNP,ET-1 and NO among different time(P ﹤ 0. 01). From the interactional effort of group and time,there were different evolvement in the serum levels of BNP,ET-1 and NO between two groups(P ﹤ 0. 01). The analysis in AMI group showed that serum ET-1 was negatively correlated with serum NO. Conclusion This study showed serum BNP and ET-1 increase and serum NO decrease after AMI,which may lay theory evidence for neural endocrine hormone change.

Key words: myocardial infarction, natriuretic peptide, brain, endothelium-dependent relaxing factors, nitrogen monoxide