Abstract: [
Abstract ] Objective Toinvestigatetheeffectsofglycyrrhizicacidinreducingtheside
effects , improving clinical symptoms and protecting liver function in the patients with
gynecologicmalignantovariancancerafterchemotherapy.Methods A totalof60casesof
patientswithovariancancerwererandomlydividedinto2groups : theobservationgroup ( n =30 )
andthecontrolgroup ( n =30 ) .Thepaclitaxel ( Toxal160-90 mg
/ m
2 ,
Day1 , 8 , 15 ) and
carboplatin ( Carbo [ AUC=5 ], Day1 ) wereusedintwogroups.Thechangesofclinicalindexes
intwogroupswerestudiedafter4cyclesofchemotherapy.Thetreatmentgroupwasgivenwith
compoundglycyrrhizininjection ( 60 mLin10% glucosesolution250 mLintravenousinfusion ,
onetimeperdayfor10consecutivedays ), thentakingcompoundglycyrrhizintablet ( 150mgone
time , 3timesoneday ) .Thechangesofleukocytes , clinicalsymptoms , liverfunction , CD3
+ ,
CD4
+ ,
CD8
+ ,
CD4
+ /
CD8
+
andprognosisinpatientsbeforeandafter4cyclesofchemotherapy
weremonitored.Results There weresignificantdifferencesintheincidenceofleukopenia ,
improvingtheabnormalliverfunction , theclinicalsymptomsandchangesofCD3
+ , CD4 + ,
CD8
+ ,
CD4
+ /
CD8
+
betweentwogroups ( P <0.05 ) .Conclusion Compoundglycyrrhizincan
improvethesidereaction , liverfunction , clinicalsymptomsandimmunosuppressioninovarian
cancerpatientsduringchemotherapy.However , ithasnoeffectontumorprognosis.

Key words: ovarianneoplasms , glycyrrhizicacid ;
chemoradiotherapy, adjuvant