Effect and clinical efficacy of lienal polypeptide injection on immune function of cervical cancer patients with neoadjuvant chemotherapy

doi:10.3969/j.issn.10073205.2016.12.015

Abstract

Abstract: [ Abstract ]
Objective Toobservetheeffectandclinicalefficacyoflienalpolypeptideinjection
onimmunefunctionofcervicalcancerpatients with neoadjuvantchemotherapy.Methods
Randomlyselected52casesofcervicalcancerpatients withneoadjuvantchemotherapy were
dividedintocontrolgroupandstudygroup.Patientsinthecontrolgroup weretreated with
paclitaxelplusnedaplatinchemotherapy , whilethepatientsinthestudygroupweretreatedwith
chemotherapyandLienalPolypeptideInjection.Theshort-term efficacy , adversereactionand
immunefunction werecomparedbetweenthe2groups.Results Theresponserateofstudy
groupandcontrolgroupwas65. 4% and61. 5%respectively , withoutsignificantdifference ( P >
0.05 ) .Thearrestofgastrointestinalreaction , bonemarrow , neurotoxicityandimpairmentof
liverfunctionofthestudygroupweresignificantlylowerthanthatinthecontrolgroup , andthe
differencewasstatisticallysignificant ( P <0.05 ) .ThemeanvaluesofCD3
+ ,
CD4
+ ,
CD8
+
and
NK cellsinthestudy group wereimprovedto certain differentdegrees , with statistical
significancecompared withthecontrolgroup ( P <0.05 ) .Conclusion Thelienalpolypeptide
injectioncanimprovetheimmunefunction , reducethesideeffectsofchemotherapy , andhasthe effectofreducingtoxicityandincreasingtheefficiency.

Key words: uterinecervicalneoplasms , chemoradiotherapy, adjuvant , immunefunction

HAN Hua1， WEI Qiang2， QIU Gang3， LI Jie1， YAN Ping1. Effect and clinical efficacy of lienal polypeptide injection on immune function of cervical cancer patients with neoadjuvant chemotherapy[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.12.015.

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Effect and clinical efficacy of lienal polypeptide injection on immune function of cervical cancer patients with neoadjuvant chemotherapy

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