Abstract: [ Abstract ] Objective To observe the effects of dexamethasone combined with
dexmedetomidineoninterscalenebrachialplexusblock.Methods Sixtypatiensscheduledfor
upperextremitysurgerywithinterscalenebrachialplexusblockwererandomlydividedintothree
groups , with20casesineachgroup.Controlgroup (
groupC ) wasgiven0.5% ropivacaine25
mL ; Dexmedetomidinegroup ( groupD ) wasreceived0.5%ropivacaine+1 μ g / kgdexmedetomidine25
mL ; dexamethasonecombinedwithdexmedetomidinegroup ( groupDD ) wasinjectedwith0. 5%
ropivacaine+1 μ g / kgdexmedetomidineanddexamethasone10 mg25 mL.Hearrate ( HR ),
meanarterialpressure ( MAP ), oxygensaturation ( SpO 2 ) and OAA / Sscoreatthetimeof
enteringtheoperatingroom ( T 0 ), beginningoftheoperation ( T 1 ), 30 minafterthestartof
operation ( T 2 ), attheendofthesurgery ( T 3 ) wereobserved.Theonsettimeanddurationof
sensoryand motorblock wererecorded.Theadverseeffectssuchasadversecardiovascular
events , excessivesedation , nauseaandvomitingwerealsorecorded.Results Thedifferencein
OAA / SscoreandHR , interblockandtimedissimilarityinthethreegroupsatthegroupsand
timepointswerestatisticallysignificant ( P <0.05 ) .However , therewasnosignificantdifference intheinteractionbetweengroupandtime ( P >0.05 ) .InOAA / SscoreandHR , interblockand
timedissimilarityofthethreegroupshadstatisticallysignificantdifference.There wasno
significantdifferenceininteractionofinterblockwithtimedissimilaritybetweenthethreegroups.
ForMAP , therewerestatisticallysignificantdifferencesintimedissimilarityamongthethree
groups ( P <0.05 ) .Therewasnosignificantdifferenceininterblockandinteractionofinterblock
withtimedissimilaritybetweenthethreegroups ( P >0.05 ) .ForSpO 2 , therewasnosignificant
differenceamongthethreegroups ( P >0.05 ) .ComparedwithgroupC , theonsettimewas ( P >
0.05 ) .ComparedwithgroupC , theonsettimewassignificantlyshortened , andthedurationof
blockwasprolonged ( P <0.05 ) ingroupDandgroupDD.ComparedwithgroupsD , theduration
ofblockwasprolongedingroupsDD ( P <0.05 ) .Theincidenceofnauseaandvomitingingroup
DDwassignificantlylowerthaningroupD.SomepatientsdevelopedbradycardiaingroupsDand
DD.Conclusion Dexamethasonecombined withdexmedetomidinecanenhancetheanalgesic
effectofropivacaine , shortentheonsettime , prolongtheactiontime , reducetheadverse
reactions , butmayinducebradycardia

Key words: dexamethasone , dexmedetomidine , anesthesia