Abstract:

Objective To investigate the safety and efficacy of remimazolam combined with fentanyl in anesthesia in daytime operation.

Methods A total of 100 patients undergoing anesthesia in daytime operation in Qinhuangdao Military Industry Hospital were selected and randomly divided into control group and research group, with 50 cases in each group. The control group was given propofol combined with fentanyl for anesthesia, and the research group was given remimazolam combined with fentanyl for anesthesia. Propofol or remazolam was added when body movement occurred during the operation until the body movement disappeared. Heart rate(HR), oxygen saturation(SpO2) and mean arterial pressure(MBP) from entering the operating room to leaving the operating room were recorded between two groups. Alertness/sedation score(OAA/S) was used to evaluate the sedation state of the two groups. The proportion of intraoperative body movement, recovery time, residence time in recovery room and incidence of adverse reactions were recorded.

Results There was no significant difference in HR, MAP, SpO2 and OAA/S scores of the group from the beginning of operation(T1) to the end of operation(T3), as compared with those before operation(T0)(P＞0.05). HR, MAP, SpO2 and OAA/S scores of the control group at T1-T3 were significantly lower than those of T0(P＜0.05). The scores of HR, MAP, SpO2 and OAA/S at T1, T2 and T3 were higher in research group than in the control group(P＜0.05). The body movement ratio, recovery time and residence time in the recovery room were smaller or shorter in the research group than in the control group(P＜0.05). The incidence of adverse reactions such as drowsiness, hypotension and respiratory depression in the research group was significantly lower than that in the control group(P＜0.05).

Conclusion Compared with propofol, remimazolam combined with fentanyl for anesthesia is more helpful to maintain the stability of vital signs, shorten the postoperative recovery time and reduce the incidence of adverse reactions.

Key words: alfentanil, anesthesia, remimazolam