Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate whether the use of progesterone is related to the incidence of gestational diabetes mellitus(GDM).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Six hundred and sixtythree cases of pregnant women with low progesterone level in early pregnancy selected, and application of progesterone therapy in 424 cases of pregnant women as a group, 239 pregnant women who did not use progestin during the same period as a control group. In the observation group, 185 cases of oral administration and 239 cases of intramuscular injection were divided into two groups according to the difference of the way of administration and the total dose of the administration(including 106 small dose groups, 46 cases of medium dose group and 87 cases of large dose group). The incidence of GDM among groups was compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The incidence of GDM in the observation group was greater than that of the control group(P＜005). There was no significant difference in the incidence of GDM in the oral group with the control group(P>005). The incidence of GDM in oral group was less than that of intramuscular injection group(P＜005). The incidence of GDM in intramuscular injection group was greater than that in the control group(P＜005). The incidence of GDM in the small dose group was significantly lower than that in the medium dose group and the large dose group(P＜005). The incidence of GDM in the middle dose group was significantly lower than that in the large dose group(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The application of progesterone is related to the incidence of GDM. The incidence of GDM was not significantly affected by oral administration, and the incidence of GDM was 〖JP2〗increased by intramuscular injection, and the higher the total dose, the greater the incidence of GDM.

Key words: diabetes, gestational, progestins, early pregnancy