Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the clinical effect of tirofiban in the treatment of coronary artery bypass surgery in patients with acute ST elevation myocardial infarction.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓According to the principle of random, one hundred and eighty patients with acute ST segment elevation myocardial infarction were divided into experimental group and control group, The control group was treated with low molecular weight heparin on the basis of conventional treatment. The patients in the experimental group were treated with tirofiban and low molecular weight heparin on the basis of routine treatment. The proBNP, ECG, ST segment drop, postoperative echocardiography, cardiac function changes and major adverse cardiovascular events were compared between 2 groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After the operation, the level of 2 groups of proBNP was increased first and then decreased. The trend of the test group was less than that of the control group. There were statistical differences between 2 groups in the intergroup, time point, intergroup time point and time point(P＜005). The ST segment dropping rate of the electrocardiogram was higher than that of the control group at the moment after the operation, and the drop rate of ST in the experimental group 1 h and 12 h was higher than that of the control group after the operation, and the rate of decrease was higher in the experimental group than in the control group(P＜005). Cardiac function index of 2 groups after first weeks of echocardiography: there was no significant difference in left ventricular ejection fraction, left ventricular end diastolic diameter and left ventricular end systolic diameter(P＞005). The left ventricular ejection fraction, the left ventricular end diastolic diameter and the left ventricular end systolic diameter were significantly better than the control group fourth weeks after the operation(P＜005). The intractable myocardial ischemia and angina pectoris in the experimental group were lower than those in the control group, and the difference was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Tirofiban can significantly improve the clinical effect of coronary artery bypass surgery for patients with acute ST segment elevation myocardial infarction.

Key words: myocardial infarction； tirofiban, coronary vessels