Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the effect of endexpiratory positive pressure on intracranial pressure in patients with poorgrade aneurysmal subarachnoid hemorrhage and severe respiratory dysfunction.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thrity  cases of poorgrade aneurysmal subarachnoid hemorrhage combined with severe respiratory dysfunction were divided into 19 cases with neurogenic pulmonary edema and 11 cases without neurogenic pulmonary edema group. PEEP was set up to 0 cmH2O, 6 cmH2O and 12 cmH2O to observe the changes of vital signs and intracranial pressure.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓When PEEP was 12 cmH2O, the intracranial pressure and central venous pressure were significantly higher than that of PEEP 0 cmH2O and PEEP 6 cmH2O. When PEEP was 12 cmH2O, the cerebral perfusion pressure was significantly lower than that of 0 cmH2O. There were statistically significant differences(P＜005). There was no significant difference in intracranial pressure, cerebral perfusion pressure and central venous pressure between the two groups at different end expiratory pressure(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Poorgrade aneurysmal subarachnoid hemorrhage combined with severe respiratory dysfunction in patients with severe respiratory dysfunction can significantly increase intracranial pressure and decrease cerebral perfusion after＞12 cmH2O, which is not related to the occurrence of neurogenic pulmonary edema.

Key words: subarachnoid hemorrhage, pulmonary edema, respiratory insufficiency