Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the plasma miRNA155 level in patients with poorgrade aneurysmal subarachnoid hemorrhage(SAH) and predict the occurrence of neurogenic pulmonary edema(NPE).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirty patients with high grade aneurysmal subarachnoid hemorrhage were selected, including 11 cases of neurogenic pulmonary edema after subarachnoid hemorrhage, 19 cases of subarachnoid hemorrhage without neurogenic pulmonary edema, and 20 cases of physical examinees at the same time as a control group, and the levels of plasma miRNA155 were detected in 3 groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The level of plasma miRNA155 in patients with poorgrade subarachnoid hemorrhage with neurogenic pulmonary edema and non neurogenic pulmonary edema was higher than that in the control group. The level of plasma miRNA155 in patients with high grade subarachnoid hemorrhage with neurogenic pulmonary edema was higher than that of high grade subarachnoid hemorrhage without neurogenic pulmonary edema. There was a significant difference in the interaction between patients and between groups(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Plasma miRNA level is significantly higher in patients with subarachnoid hemorrhage with neurogenic pulmonary edema. Elevated miRNA can predict the occurrence of neurogenic pulmonary edema after poorgrade subarachnoid hemorrhage.

Key words: subarachnoid hemorrhage, pulmonary edema, microRNAs