Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the clinical values of acetylcysteine effervescent tablets in prevention of radiation pneumonitis for patients with nonsmall cell lung cancer(NSCLC).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 68 consecutives as NSCLC were enrolled and divided randomly into control and observation groups, each with 34 cases, Control group was received intensitymodulated radiation, observation group was adopted oral acetylcysteine effervescent tablets. The differences of lung function forced expiratory volume in first second (FEV1), forced vital capacity(FVC), serum interleukin6(IL6), tumor necrosis factorα(TNFα) levels and the rates of radiation pneumonia and bone marrow suppression were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The values of FEV1 and FVC in control group after treatment were lower than before treatment(P＜005),while there were no statistical difference in observation group(P＞005). The values of FEV1 and FVC in observation 〖JP2〗group were significantly higher than in control group after treatmen(P＜005). The levels of IL6〖JP〗 and TNFα in the two groups were higher than that before treatment(P＜005), but observation group were still significantly lower than control group after treatmen(P＜005).The incidences of 3~5 level radioactive pneumonia and bone marrow suppression in observation group were both significantly less than that in control group(14.7% vs 35.3%, 50.0% vs 79.4%, P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓It can greatly alleviate inflammation,improve pulmonary ventilation function,reduce the radioactive pneumonia and bone marrow suppression rates in patients with NSCLC by acetylcysteine effervescent tablets.

Key words: carcinoma, nonsmallcell lung； radiation pneumonitis, acetylcysteine