Abstract: ［Abstract］Objective〖HTSS〗To observe the effects of dexmedetomidine combined with oxycodone on perioperative extubation stress response in patients with nasal endoscopic surgery.
〖HTH〗〖WTHZ〗Methods〖HTSS〗Sixty patients who underwent selective nasal endoscopic surgery were randomly divided into sufentanil group and oxycodone group, with 30 cases in each group. Sufentanil group was given 0.4 μg/kg sufentanil and 0.5-0.6 μg/kg dexmedetomidine for anesthesia induction, and oxycodone group was given 0.2 mg/kg oxycodone and 0.5-0.6 μg/kg dexmedetomidine for anesthesia induction. Mean arterial pressure(MAP), heart rate(HR), cortisol(COR) and blood glucose(GLU) were recorded before anesthesia induction(T0), at 1 min after tracheal intubation(T1), at the beginning of surgery(T2), at extubation(T3) and at 10 min after extubation(T4). The wake-up time, extubation time, extubation quality score, Ramsay sedation score and occurrence of adverse reactions were compared between two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗The MAP, HR, COR and GLU in two groups were increased first and then decreased, and the changes of MAP, HR, COR and GLU in oxycodone group were significantly lower than those in sufentanil group, and there were statistically significant differences between-group effects, time-point effects and interaction effects of between-group and time-point(P＜0.05). The extubation quality score in oxycodone group was significantly lower than that in sufentanil group while the Ramsay sedation score was significantly higher than that in sufentanil group, and the incidence rate of adverse reactions was lower than that in sufentanil group(P＜0.05). There were no significant differences in wake-up time and extubation time between two groups(P＞0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗Dexmedetomidine combined with oxycodone anesthesia induction for nasal endoscopic surgery can effectively maintain hemodynamic stability, inhibit perioperative extubation stress response, and reduce the incidence rate of adverse reactions.

Key words: nasal endoscopic surgery, stress response, dexmedetomidine, oxycodone