Abstract: ［Abstract］ Objective〖HTSS〗To assess the effects of oxidizedcellulose absorbable hemostatic gauze(OAHG) to the course of ctaneous wound.
〖HTH〗〖WTHZ〗Methods〖HTSS〗A total of 24 Wistar rats were used. Three full-thickness excisional wounds were made on each side of the dorsal midline with a 15 mm punch biopsy in one rat. Two wounds were covered with OAHG and surgicel and one wound was used as blank control studies(no gauze). Wound-closure kinetics were observed.  Histological sections of day4, 7 , 14 and 21 wounds were analyzed，Expression of α-smooth muscle actin(α-SMA) within the granulation tissue and collagen formation were evaluated.
〖HTH〗〖WTHZ〗Results〖HTSS〗Course of the wound-closure kinetics were not significantly different in three groups： Histological analysis showed that a dehydrated crust, granulation tissue and collagen formmationin in three groups，granulation tissues were formed at margeing of excisional wounds by day 4, peaked at day 7.  Formation of the collagen increased at day 14 and epithelial cells coveried all wound in three groups at day 21. Expressive patterns of α-SMA were similar to the three groups but the peaks of α-SMA expression in both gauze groups were lower and delayer than in black control.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗OAHG does not affect the healing of skin wounds in rats, and there is no significant difference between domestic and foreign similar products(instant gauze).

Key words: wound healing, surgical sponges, α-smooth muscle actin, rats