Abstract: ［Abstract］Objective〖HTSS〗To analyze the value of intrathecal injection of isoniazid plus dexamethasone combined with saline replacement in the treatment of tuberculous meningitis.
Methods〖HTSS〗A total of 78 patients with tuberculous meningitis were selected. They were randomly divided into reference group(intrathecal injection of isoniazid plus dexamethasone) and observation group(control group combined with equal amount of normal saline replacement treatment). The therapeutic effects of the two groups were compared.
Results〖HTSS〗After treatment, content of protein, glucose and cell count in cerebrospinal fluid(CSF) of the two groups were lower than that before treatment, and content of chloride in CSF of the observation group was lower than that before treatment(P＜0.05). After treatment, contents of protein, glucose, cell count and chloride in CSF of the observation group were all lower than that of control group(P＜0.05). The total effective rate of observation group was higher than that of control group(P＜0.05). The adverse drug reaction rate of observation group was lower than that of control group(P＜0.05). The recovery time of headache and neck strength, CSF pressure, fever, vomiting, coma, CSF protein, CSF cell and hospitalization in the observation group were significantly shorter than those in control group(P＜0.05).
Conclusion〖HTSS〗The treatment of tuberculous meningitis by intrathecal injection of isoniazid plus dexamethasone and replacement with equal amount of normal saline has clear clinical effect, obvious improvement of clinical indicators and symptoms, ensuring the safety of treatment, shortening the length of stay and providing guarantee for early rehabilitation.

Key words: tuberculosis, meninges, isoniazid, dexamethasone, normal saline