Abstract: Objective〖HTSS〗To observe the analgesic and sedative effects of different doses of sufentanil in patient-controlled intravenous analgesia(PCIA) after maxillofacial fracture internal fixation operation and adverse reactions.
〖WTHZ〗Methods〖HTSS〗Seventy-three patients with maxillofacial fracture  were randomly divided into group A(21 cases，sufentanil 0.02  μg·kg-1·h-1), group B(27 cases，sufentanil 0.04 μg·kg-1·h-1) and group C(25 cases，sufentanil 0.06 μg·kg-1·h-1). The total amount of medication, Visual Analogue Score(VAS), Visual Analogue Fatigue Score(VAFS) and White sedation score were compared at each time point, and the occurrence of adverse effects of postoperative analgesia was counted.
〖WTHZ〗Results〖HTSS〗The VAS and VAFS scores of group B and group C were significantly lower than those of group A at 6 h, 12 h, 24 h and 48 h after operation(P＜0.05), but there was no significant difference between group B and group C at all time points after operation(P＞0.05); The White sedation scores of group C at all time points after operation were significantly higher than those of group A and group B(P＜0.05); While there was no significant difference between group A and group B at all time points(P＞0.05). The incidence of dizziness, nausea and vomiting in group A and group B was significantly lower than that in group C(P＜0.05), while there was no significant difference in the incidence of adverse reactions between group A and group B(P＞0.05).
〖WTHZ〗Conclusion〖HTSS〗Continuous infusion of sufentanil 0.04 μg·kg-1·h-1 is suitable for PCIA after maxillofacial fracture internal fixation operation, which can obtain good analgesic effect and high safety.

Key words: maxillary fractures, mandibular fractures, sufentanil