Abstract: Objective  To analyze the vaginal microecological characteristics and influencing factors of patients with ovarian cancer complicated with vaginitis, thereby providing reference for clinical prevention and treatment. 
Methods  A total of 330 ovarian cancer patients admitted were selected. The infection rate and vaginal microecological characteristics of patients with vaginitis were analyzed. Patients were divided into infection group and non-infection group according to presence or absence of vaginitis. Age, education level, underlying diseases, condom use, sexual frequency, chemotherapy, self-vaginal irrigation and history of vaginitis were compared between the two groups. Multivariate Logistic regression analysis was used to determine the influencing factors of ovarian cancer with vaginitis. 
Results  Of 330 patients with ovarian cancer,117(35.45%) were complicated with vaginitis. The top three infection types in 117 patients were vaginal candidiasis(VVC) in 35 cases(29.91%). bacterial vaginosis(BV) in 30 cases(25.64%) and microecological disorders in 28 cases(23.93%). Age ≥50 years, underlying diseases, frequency of sexual life ≥2 times/week, chemotherapy, self-vaginal irrigation and history of vaginitis were higher in infection group than in non-infection group, while junior college education or higher and condom use ratio were lower in infection group than in non-infection group, suggesting significant difference(P＜0.05). Logistic regression analysis showed that age ≥50 years, underlying diseases, frequency of sexual life≥2 times/week, chemotherapy, self-vaginal irrigation and history of vaginitis were the risk factors of ovarian cancer complicated with vaginitis(P＜0.05). Junior college education or higher and condom use were the protective factors of ovarian cancer complicated with vaginitis(P＜0.05). 
Conclusion  Ovarian cancer patients with vaginitis mainly had VVC, followed by BV. Age, underlying diseases, frequency of sexual life and chemotherapy are the risk factors of ovarian cancer complicated with vaginitis. Junior college education and condom use are the protective factors of ovarian cancer complicated with vaginitis. In clinical practice, according to the characteristics of infection and risk factors, we should correct the poor living habits related to risk factors and strengthen the popularization of knowledge on physiological health and disease prevention.

Key words: ovarian neoplasms, vaginitis, influencing factor analysis