Abstract: Objective To analyze the expression of miR-142-3p, miR-216a and miR-107-5p in patients with acute kidney injury(AKI) undergoing blood purification in ICU and their value of efficacy evaluation. 
Methods A total of 132 AKI patients who received blood purification treatment in ICU of our hospital were selected as the AKI group, and 80 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the healthy group. The expression levels of miR-142-3p, miR-216a and miR-107-5p were detected and analyzed in AKI patients undergoing blood purification in ICU. All patients received blood purification therapy. The expression levels of the above indexes before and after treatment and under different therapeutic effects were compared to analyze the efficacy evaluation value of the three indexes. 
Results Compared with those the healthy group, the expressions of miR-142-3p and miR-107-5p were increased, while the expression of miR-216a was decreased in the AKI group(P＜0.05). Compared with those before treatment, the expressions of miR-142-3p and miR-107-5p were increased, while the expression of miR-216a was decreased in AKI group after treatment(P＜0.05). According to therapeutic effect, they were divided into the effective treatment group(n=110) and the ineffective treatment group(n=22). Compared with the effective treatment group, the expressions of miR-142-3p and miR-107-5p were increased in the ineffective treatment group, while the expression of miR-216a was decreased in the ineffective treatment group(P＜0.05). Compared with surviving patients, miR-142-3p and miR-107-5p were elevated, while miR-216a was decreased in dead patients, and the difference was statistically significant(P＜0.05). ROC curve analysis showed that miR-142-3p, miR-216a and miR-107-5p all had a high value in evaluating the efficacy of blood purification in ICU for AKI patients(P＜0.05). 
Conclusion The high expression of miR-142-3p and miR-107-5p and low expression of miR-216a in AKI patients undergoing blood purification in ICU are closely related to clinical efficacy and can be used to evaluate the efficacy of patients.

Key words: acute kidney injury, renal replacement therapy, treatment outcome