Journal of Hebei Medical University ›› 2023, Vol. 44 ›› Issue (10): 1157-1161，1184.doi: 10.3969/j.issn.1007-3205.2023.10.008

Previous Articles     Next Articles

Application value of PCT, hs-CRP and sPLA2-ⅡA in clinical evaluation of sepsis

  

  1. 1.Department of Clinical Laboratory, Handan Central Hospital，Hebei Province, Handan 056001, China； 
    2.Department of Laboratory, Handan Central Hospital， Hebei Province, Handan 056001, China

  • Online:2023-10-25 Published:2023-11-03

PDF (PC)

44

Abstract: Objective To investigate application value of procalcitonin (PCT), hypersensitive C reactive protein (hs-CRP) and group ⅡA secreted phospholipase A2 (sPLA2-ⅡA) in the clinical evaluation of sepsis. 
Methods A total of 164 patients diagnosed with sepsis were retrospectively analyzed and selected as the observation group. They were divided into gram-negative bacilli group, gram-positive cocci group and fungus group. Another 125 patients without sepsis were selected as the control group. The differences inexpression levels of serum PCT, hs-CRP and sPLA2-ⅡA were compared between observation group and the control group, and the differences in expression levels of serum PCT, hs-CRP and sPLA2-ⅡA among observation groups were compared. Acute physiology and chronic health evaluation Ⅱ (APACHE-Ⅱ) scoring system was used to evaluate the severity of the disease, and the correlation between PCT, hs-CRP, sPLA2-ⅡA and APACHE-Ⅱ score was analyzed by Pearsoncoefficient analysis. The diagnostic value of PCT, hs-CRP, sPLA2-ⅡA and their combination for sepsis was analyzed by receiver operating characteristic (ROC) curve. 
Results The expressions of PCT, hs-CRP and sPLA2-ⅡA in gram-negative bacilli group and gram-positive cocci group were higher than those in the control group (P＜0.05), and the expression of sPLA2-ⅡA was higher in fungus group than in the control group(P＜0.05). The expression of sPLA2-ⅡA in patients with APACHE-Ⅱ score ≥15 was significantly higher than that in control group (P<0.01). PCT, hs-CRP and sPLA2-ⅡA were all positively correlated with APACHE-Ⅱ score, and the correlation of sPLA2-ⅡA (r=0.562, P＜0.01) was higher than that of PCT (r=0.400, P＜0.01) and hs-CRP (r=0.562, P＜0.01). sPLA2-ⅡA (AUC=0.86) had higher diagnostic value for sepsis than PCT (AUC=0.71) and hs-CRP (AUC=0.65), and the combined detection of the three (AUC=0.93) had higher diagnostic efficacy. 
Conclusion Compared with PCT and hs-CRP, sPLA2-ⅡA detection has potential application value in clinical evaluation of sepsis. 


Key words: sepsis, C-reactive protein, procalcitonin