Journal of Hebei Medical University ›› 2023, Vol. 44 ›› Issue (8): 941-944,951.doi: 10.3969/j.issn.1007-3205.2023.08.013

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Predictive value of blood lactate and procalcitonin clearance rates for prognosis in patients with burn shock

  

  1. 1.Department of Burn Plastic Surgery, Liyang People′s Hospital, Jiangsu Province, Changzhou 
    213000, China; 2.Department of Burn Plastic Surgery, the Second Affiliated Hospital of 
    Chengdu Medical College, Sichuan Province, Chengdu 610000, China

  • Online:2023-08-25 Published:2023-08-28

Abstract: Objective To explore the predictive value of early blood lactate clearance rate and procalcitonin clearance rate (PCTc) for prognosis of patients with burn shock. 
Methods A total of 96 patients with burn shock admitted to Liyang People′s Hospital were selected, and the 28-day survival during hospitalization was calculated. The clinical data of the survival group and the death group were compared. Multivariate Logistic analysis of factors affecting the prognosis of patients was performed. The predictive value of early blood lactate clearance rate and PCTc for death of patients with burn shock was analyzed. 
Results The mortality rate of burn shock patients was 38.54%. The proportion of inhalation injury, Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score and sequential organ failure assessment (SOFA) score in the death group were higher (P<0.05), while the albumin, 6-h lactate clearance rate and 6-h PCTc in the death group were lower (P<0.05). Logistic regression analysis showed that APACHE Ⅱ score (OR=2.804, 95%CI: 1.037-4.085), SOFA score (OR=2.930, 95%CI: 1.256-4.978), 6-h blood lactate clearance rate (OR=3.089, 95%CI: 1.843-6.012), and 6-h PCTc (OR=3.428, 95%CI: 2.157-7.483) were all risk factors affecting death of burn shock patients (P<0.05). ROC analysis showed that the AUC of combination of 6-h lactate clearance rate and 6-h PCTc in predicting the death of burn shock patients was 0.816 (95%CI: 0.721-0.891), which was higher than that of 6-h lactate clearance rate [0.654 (95%CI: 0.551-0.746)] and 6-h PCTc [0.703 (95%CI: 0.602-0.785)] in predicting the death of burn shock patients alone (P<0.05). 
Conclusion Early blood lactate clearance rate and PCTc have high predictive value for death of burn shock patients. 


Key words: blood lactate clearance rate, procalcitonin clearance rate, burn shock, prognosis