Abstract: Objective To study the clinical effects and adverse reaction of different chemotherapies for patients with multi-drug resistant pulmonary tuberculosis.Methods Eighty-one patients with multi-drug resistant pulmonary tuberculosis were randomly divided into A group(moxifloxacin and amikacin group,41 cases)and B group (levofloxacin and capreomycin group,40 cases ),then the clinical manifestations,sputum negative conversion rate,image performance and adverse reaction before and after treatment were compared between two groups. Results The clinical effect,sputum negative conversion rate and the image performance of A group at early treatment(treatment at two months)were superior to those of group B(P <0.05). However,there were no significant differences in adverse reactions between two groups (P >0.05).Conclusion The 6 MfxAmpaZE/18 Mfx PaZE prescription in the treatment of multi-drug resistant pulmonary tuberculosis is safe and effective,especially in the early treatment stage.

Key words: tuberculosis, pulmonary, extensively drug-resistant tuberculosis, drug toxicity