Abstract: Objective To look for the scientific method which could apply to research the relationships between typhoid fever incidence and meteorological factors,and to discuss the meteorological epidemiology characteristics of typhoid fever.Methods The data of typhoid fever, meteorological parameters and population in 1991-2010 in Handan were collected and analyzed. Results ①Collinearity diagnosis of meteorological parameters showed that the minimal tolerance was 0.014 and the maximal variance inflation factor was 73.264.②Monthly incidence of typhoid fever had significant positive correlation with monthly mean temperature,monthly extreme minimum temperature,monthly extreme maximum temperature,monthly small evaporation, monthly total precipitation,monthly sunshine hours and monthly average relative humidity,and significant negative correlation with monthly average air pressure by using Spearman correlation analysis (P<0.05 or <0.01 ).The correlation coefficient of typhoid fever and monthly mean temperature was the biggest(rs=0.592).③The result of KMO and Bartlett showed that test of meteorological parameters was very suitable for factor analysis.Conclusion The problem of multicollinearity in 10 meteorological parameters was very serious.Monthly mean temperature was the main meteorological factor influencing typhoid fever incidence.The non natural water factor was the main factor affecting typhoid fever incidence.

Key words: typhoid fever, medical, meteorology, epidemiology, factor analysis