Abstract: Objective To investigate the expression of T-box protein 2 (TBX2)and anti-oncogene FEZ1 in normal gastric muscosa,intraepithelial tumor and gastric adenocarcinoma and the roles of their clinic pathology.Methods The exprssion of TBX2 and FEZ1 were detected by immunohistiochemistry in normal gatromucosa,intraepithelial tumor and gastric carcinoma. Statistic soft ware SPSS1 5 .0 was used to analyze the clinicopathological significance and its relationship to prognosis.Results The positive expression rate of TBX2 protein was higher in low differentiated group than in high differrentiated one (P<0.05),and TBX2 in group with stageⅣwas also higher than in group with stageⅠ(P<0.05),and also in group with over one half deeply muscle infiltration was significantly higher than in group with under one-half infiltration (P<0.05).The positive expression rate of FEZ1 protein was lower in low differentiated group than in high differrentiated one (P<0.05),so was it in group with tumor diameter over 4cm than in group under 4cm (P<0.05 );the expression rate of FEZ1 was lower in group with over 1/2 muscle infiltration than in group with under1/2 infiltrattion,so was it in group with lymph nodule metastasis than in group without lymph nodule metastasis(P<0.05);also it was higher in group with the age over 60 years old than in group under 60 years old (P<0.05).Conclusion TBX2 and FEZ1 were of great importance in the development and prognosis of gastric adenocarcinoma. The former played an important role of oncogene with the latter anti-oncogene.

Key words: stomach neoplasm, pathology, clinical, immunohistiochemistry