Abstract: Abstract］ ObjectiveTo analyze the correlation between the concentration of serum C reactive protein(CRP) and plaque composition in patients with unstable angina pectoris. MethodsRetrospective analyzed 43 patients with unstable angina pectoris were performed. Intravascular ultrasoundvirtual histology(VHIVUS) examination in a culprit lesion was used. Patients were divided into thincap fibroatheroma(TCFA) group or stable plague group according to VHIVUS. Enzyme linked immunosorbent assay was used to detect serum CRP and to study the correlation between CRP and plaque composition. ResultsThere were no diffirence in minimal luman area, minimal luman diameter, external elastic membrane between the two groups. TCFA group had larger plague burden than stable plague group(P＜0.05). Virtual histology analysis showed TCFA group had lower fibrous ratio than stable plague group（P＜0.05）； and TCFA group had higher necrotic core ratio than stable plague group(P＜0.05）. Spearman correlation analysis showed that CRP  was positively correlated with necrotic core (rs=0.421, P=0.005) and negatively correlated with fibrous tissue(rs=-0.411, P=0.009). ConclusionThe formation of thin fibrous cap was accompanied with the increase of CRP in patients with unstable angina pectoris. serum level of CRP increased in patients with TFCA. The level of CRP was positively correlated with the ratio of necrotic core and negatively correlated with the proportion of fibrous tissue.

Key words: coronary disease, Creactive protein, ultrasound