Abstract: ［Abstract］ 〖JP2〗Objective〖HTSS〗〓To detect the expression of osteopontin(OPN) in tissues of endometrial〖JP〗 carcinomas and to analyze its relationship with clinicopathologic features(age, clinical and surgical stage, histodifferentiation, myometrial invasion, histological type, lymph node metastasis) in order to investigate the effect on the prognosis of endometrial carcinoma.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and seventyone patients by pathological examination to be endometrial carcinoma were selected. The expression of OPN was identified by immunohistochemically SP method in 171 paraffin block. The relationship on the OPN expression and the prognosis of endometrial carcinoma was discussed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive expression rate of OPN was 63.74%(109/171) in 171 patients with endometrial carcinoma. The differences of OPN positive status with different situation of clinical and surgical stage, histodifferentiation, myometrial invasion and lymph node metastasis were statistical significance(P＜005). KaplanMeier method showed that OPN, clinical and surgical stage, myometrial invasion and lymph node metastasis were related with survival rate of endometrial carcinoma(P＜005). Cox analysis showed that OPN, clinical and surgical stage, myometrial invasion were risk factors of endometrial carcinoma prognosis.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓OPN was an important factor effect on prognostic of endometrial carcinoma, and it had a great clinical significance in judging prognostic and guiding clinical treatment of endometrial carcinoma.

Key words: endometrial carcinoma, osteopontin, immunohistochemistry, prognosis