Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate ultrasonographic characteristics， acoustic radiation force impulse imaging（ARFI） values and pathological findings of rabbit liver damage after using chemotherapeutic agents.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirty female New Zealand rabbits were randomly divided into 3 groups， group A（control group）， group B（cyclophosphamide+epirubicin group）， group C（cyclophosphamide+epirubicin+fat emulsion group）. The liver function and blood lipid were measured before and after treatment. The rabbit liver was examined by conventional ultrasound and acoustic radiation force imaging. After 6 cycles of chemotherapy drugs, the liver function, blood lipid, conventional ultrasound and shear wave velocity were compared before and after treatment and livers were taken out for pathological observation.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no significant difference in AST and ALT before and after treatment in group A（P＞005）. AST and ALT in group B and group C were markedly elevated after drug use （P＜005）, and were higher than group A. AST and ALT in group C were higher than group B （P＜005）. There was no significant difference in TC before and after treatment in group A(P＞005), B in group C and group TC were higher than those before treatment(P＜005), the TC values of B group and C group after treatment were higher than those of A group, C group was higher than B group. There was no significant difference in TG between the A group and the B group before and after treatment(P＞005), the TG in the C group was significantly higher than that before treatment(P＜005), and the TG in the C group was significantly higher than that in the A group and the B group(P＜005). There was no abnormality in A group after placebo. After using chemotherapy in B group, C group, liver routine ultrasound examination revealed hepatic capsular thickening, volume slightly enlarged, plump shape, different degrees of echogenic, uneven, bile duct wall and portal vein wall echogenic extrahepatic bile duct and portal vein were dilated, C group was more obvious. There was no significant difference in shear wave velocity before and after treatment in A group（P＞005）. The shear wave velocity of B group and C group was higher than that before treatment(P＜005), and the shear wave velocity of B group and C group after treatment was higher than that of A group(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓 A shortmiddle term administration of chemotherapeutic agents is not able to cause prominent fatty liver. ARFI can be utilized as a useful method for the quantitative evaluation of liver lesion caused by chemotherapeutic agents.

Key words: fatty liver, ultrasonography, acoustic radiation force impulse imaging