Abstract: ［Abstract］〓Objective〖HTSS〗〓To explore the clinical efficacy and mechanism of rosuvastatin combined with bicyclol tablets on nonalcoholic steatohepatitis(NASH).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 120 NASH patients were randomly divided into the rosuvastatin treatment group and the rosuvastatin combined with bicyclol tablets, 60 patients in each group. The changes of serum liver function, blood lipid and liver fibrosis index as well as liver tissues fibrosis related index were observed before and after treatment in the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After treatment, the glutamic pyruvic transaminase(ALT), glutamyl transpeptadase(AST) and glutamyl transpeptadase(GGT) levels of the two groups were significantly lower than that before treatment, and the ALT, AST and GGT levels of the R+D group were significantly lower than those of the R group, with statistically significant differences(P＜005). After treatment, 2 groups of total cholesterol(TC), triglyceride(TG) and low density lipoprotein cholesterol(LDLC) level was lower than that before treatment, high density lipoprotein cholesterol(HDLC) were significantly higher than those before treatment, the difference was statistically significant(P＜005). There was no significant difference in TC, TG, HDLC and LDLC levels between the two groups after treatment(P＞005). Hyaluronic acid(HA),  laminin(LN), procollagen Ⅲ(PCⅢ) and collagen Ⅳ(CⅣ) level of R+D groups was lower than that before treatment, HA, LN, PCⅢ and CⅣof R+D group was lower than that in R group, the difference was statistically significant(P＜005). The mRNA and protein expressions of collagen Ⅰ, collagen Ⅳ and fibronectin in the liver of R+D group were significantly lower than those before treatment, and the mRNA and protein expressions of collagen Ⅰ, collagen Ⅳ and fibronectin in the liver of R+D group were significantly lower than those of the R group, with statistically significant differences(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The indexes of liver function and liver fibrosis in NASH patients were significantly improved after the combined treatment of rosuvastatin and bicyclol tablets, and the curative effects were superior to that of rosuvastatin alone.

Key words: fatty liver, nonalcoholic steatohepatitis, rosuvastatin;bicyclol tablets