Abstract: ［Abstract］ Objective〖HTSS〗To explore effect of 5-aminolevulinic acid photodynamic treatment(ALA-PDT) combined with tetracaine hydrochloride mucilage on the treatment of condylomata acuminata and influence of serum of lymphotactin(LTN), tumor necrosis factor α(TNF-α) and substance P(SP).
〖HTH〗〖WTHZ〗Methods〖HTSS〗Eighty-two cases of condylomata acuminata patients were equally divided into control group and observation group by the digital random table. Patients in the control group were treated with ALA-PDT, patients in the observation group were treated with ALA-PDT combined with tetracaine hydrochloride mucilage. The clinical effect, recurrence, adverse reactions and the serum level of LTN, TNF-α, SP of two greoups were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗The clinical efficacy and total effective rate of the observation group were higher than those of the control group(P＜0.05). The recurrence rate and the average number of recurrence warts in the observation group were significantly lower than those in the control group(P＜0.05). The serum LTN in the control group and the observation group after treatment was significantly higher than that before treatment(P＜0.05), and the serum TNF-a and SP in the two groups were significantly lower than those before treatment(P＜0.05). The serum LTN in the observation group was significantly higher than that in the The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P＜0.05), while the incidence of TNF-α and SP in the observation group was significantly lower than that in the control group(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗ALA-PDT combined with tetracaine hydrochloride gel has excellent curative effect on condyloma acuminatum, low recurrence rate and less adverse reactions. It can regulate local cellular immunity by increasing LTN level and decreasing TNF-alpha and SP level, which is worthy of clinical reference and application.

Key words: condylomata acuminata, 5-aminolevulinic acid photodynamic treatment, tetracaine hydrochloride, serum factor