Abstract: ［Abstract］ Objective〖HTSS〗To investigate the changes of abnormal blood glucose, platelet count, white blood cell count and C-reactive protein in children with neonatal sepsis with different pathogenic bacteria.
 〖WTHZ〗Methods〖HTSS〗A total of 108 children with neonatal sepsis were selected. According to the type of blood culture pathogens, the children were divided into 46 Gram-positive bacteria groups, 43 Gram-negative bacteria groups and 19 fungal groups. The general data of the three groups were analyzed. The clinical manifestations were compared with changes in blood glucose abnormalities, platelet counts white blood cell counts and C-reactive protein in the three groups.
 〖WTHZ〗Results〖HTSS〗Among 108 cases of neonatal sepsis, 46 Gram-positive bacteria(42.59%) were infected, of which coagulase-negative staphylococci(24.07%) and Enterococcus faecium(9.26%) were the main infections; 43 were Gram-negative bacteria. Cases(39.81%), of which E. coli(21.30%) and Klebsiella pneumoniae(14.81%) were predominant; 19 cases(17.60%) were infected with fungi, of which Candida albicans(9.26%) was the Lord. The gestational age and birth weight of the Gram-positive bacteria group were much better than those of the Gram-negative bacteria group and the fungal group, and the differences in gestational age and birth weight among the three groups of children were statistically significant(P＜0.05). The age was significantly larger than that of the Gram-positive bacteria group and the Gram-negative bacteria group, and the age of onset of the Gram-negative bacteria group was significantly larger than that of the Gram-positive bacteria group(P＜0.05). The proportion of abnormal blood glucose in the Gram-negative bacteria group and the fungal group(34.88%, 31.58%) was significantly higher than that in the Gram-positive bacteria group(13.04%)(P＜0.05); The fungal group had abnormal white blood cell counts and elevated C-reactive protein levels. The proportion of Gram-negative bacteria was significantly lower than that of the Gram-positive bacteria group and the Gram-negative bacteria group, and the proportion of C-reactive protein levels in the Gram-negative bacteria group was significantly higher than that of the Gram-positive bacteria group(P＜0.05). The percentage of platelet count reduction in the group and fungal group was significantly higher than that in the Gram-positive group(P＜0.05).
 〖WTHZ〗Conclusion〖HTSS〗When the abnormal white blood cell counts and C-reactive protein levels in children with neonatal sepsis are significantly higher, the probability of bacterial infection is greater; When the platelet count is significantly lowered, it is more likely to be infected with Gram-negative bacteria and fungi. And the proportion of abnormal blood glucose in Gram-negative bacteria group and fungal group was significantly higher than that in Gram-positive bacteria group.

Key words: bacteremia, platelet count, white blood cell count, C-reactive protein