Abstract: Objective  To investigate the results of bacterial culture of pus as well as antibiotic sensitivity in patients with acute appendicitis during pregnancy and to provide basis for future clinical treatment.
  Methods  We selected 164 cases of pregnant patients with acute appendicitis as research objects. The pathogen culture and drug sensitivity analysis of pus samples were conducted.
  Results  A total of 106 pathogenic bacteria were detected in 102 specimens of 164 samples. Gram-negative bacteria accounted for 93.40%, mainly including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa, accounting for 66.98%, 9.43% and 7.55% respectively. Drug sensitivity analysis showed that Escherichia coli were sensitive to meropenem, imipenem, cefoxitin, piperacillin/tazobactam, cefoperazone/sulbactam, ticarcillin/clavulanic acid and amoxicillin/clavulanic acid. The sensitivity rate was≥85.00%; while Klebsiella pneumoniae was sensitive to meropenem, imipenem, cefoxitin, piperacillin/tazobactam, amoxicillin/clavulanic acid, cefepime, cefoperazone/sulbactam, ticarcillin/clavulanic acid. The sensitivity rate was≥90.00%, and Pseudomonas aeruginosa was sensitive to meropenem, imipenem, cefoxitin, cefepime, piperacillin/tazobactam, ticarcillin/clavulanic acid, amoxicillin/clavulanic acid, ceftazidime and cefoperazone/sulbactam. The sensitivity rate was≥85.00%. The sensitivity was greater than or equal to 85.00%. The most sensitive antibiotics of the three main pathogenic bacteria were meropenem and imipenem, with an effective rate of 100.00%. Cefoxitin, piperacillin/tazobactam, cefoperazone/sulbactam, ticarcillin/clavulanic acid and amoxicillin/clavulanic acid were more than 85.00% sensitive.
  Conclusion  Gram-negative bacteria are the main infections in patients with acute appendicitis during pregnancy. Meropenem and imipenem can be used as the main antibiotic alternatives. Other effective drugs include cefoxitin, piperacillin and cefoperazone. In clinic, the appropriate antibiotics should be selected according to the characteristics of medication for pregnancy.

Key words: pregnancy, acute appendicitis, pathogenic bacteria