Abstract: Objective  To explore the clinical effects of noninvasive positive pressure ventilation(NIPPV) combined with drugs in the treatment of acute left heart failure. 
Methods  A total of 104 patients with acute left heart failure were selected as study subjects. According to the random number table method, the patients were divided into combined group and control group, with 52 cases in each group. Control group was given only conventional drug therapy, and combination group was combined with NIPPV on this basis. The plasma heart failure markers ［cardiac troponin  I(cTnI), N-terminal pro-brain natriuretic peptide(NT-proBNP), mid-atrial natriuretic peptide(MR-proANP)］, inflammatory factors ［interleukin-6(IL-6), C-reactive protein(CRP), tumor necrosis factor-α(TNF-α)］ and arterial blood gas indicators ［partial pressure of oxygen(PaO2), partial pressure of carbon dioxide(PaCO2), base excess(BE)］ and echocardiographic indexes ［left ventricular ejection fraction(LVEF), stroke volume(SV), cardiac index(CI)］ were compared between two groups before treatment and after 3 d of treatment. 
Results  After 3 d of treatment, the levels of plasma cTnI, NT-proBNP, MR-proANP, IL-6, CRP, TNF-α and PaCO2 in two groups were significantly lower than those before treatment, and the levels in combined group were significantly lower than those in control group at the same time(P＜0.05). The levels of PaO2, BE and LVEF, SV and CI in two groups were significantly higher than those before treatment, and the levels in combined group were significantly higher than those in control group at the same time(P＜0.05). 
Conclusion  NIPPV combined with drugs for acute left heart failure can achieve ideal efficacy, and it is beneficial to control the body inflammatory response, stabilize the internal environment balance and restore cardiac function as soon as possible.

Key words: heart failure, continuous positive airway pressure, biological markers