Abstract: ［Abstract］ObjectiveTo investigate the clinical effect of nasal continuous positive airway pressure ventilation combined with 3% hypertonic saline aerosol inhalation in the treatment of severe bronchiolitis.
〖WTHZ〗MethodsChildren(106 patients) with severe bronchiolitis were sorted according to the electronic medical records. These children were randomly divided into observation group and control group, with 53 cases in each group. On the basis of routine treatment, nasal continuous positive airway pressure ventilation was given priority in both groups for patients who suffered from dyspnea, and inhalation of 3% hypertonic saline by atomization was given to the observation group. At the time of admission and 24, 48, 72 hours after treatment, the severity scores, hospitalization time and adverse reactions were respectively compared between the two groups.
〖WTHZ〗ResultsThe severity scores of both groups showed a decreasing trend, and the score of the observation group decreased significantly. There were significant differences for the severity scores between groups, time point after treatment and the interaction of groups and time points(P＜0.05 or P＜0.01). The hospital stay of the observation group was shorter than that of the control group, and no significant adverse reactions occurred in the both groups.
〖WTHZ〗Conclusion3% hypertonic saline aerosol inhalation combined with nasal continuous positive airway pressure ventilation in the treatment of severe bronchiolitis has significant clinical effect, improves the prognosis of the disease, and reduces the incidence of adverse reactions, which is worthy of clinical application.

Key words: bronchiolitis, continuous positive airway pressure； saline solution, hypertonic