Abstract: Objective To study the relationship between the level of hormone and plasma inflammatory markers and coronary plaque stability in female patients with coronary heart disease before menopausal period. 
Methods A total of 62 pre-menopausal female patients with coronary heart disease(CHD) diagnosed by coronary angiography were selected.According to the clinical manifestations of the patients, they were divided into acute coronary syndrome(ACS) group(n=30) and stable angina pectoris(SAP) group(n=32). At the same time, the patients with normal coronary angiography were selected as the control group(n=30). The distribution of plaques in ACS group and SAP group was examined by intracoronary ultrasound imaging. The level of plasma sex hormone(E2, P) were measured by chemiluminescence in all subjects. The level of Hcy and MPO were measured by double antibody sandwich enzyme-linked immunosorbent assay. The correlation between the level of hormone and plasma inflammatory markers in female patients with coronary heart disease(CAD) before menopausal period were analyzed. 
Results There was significant difference in the proportion of unstable plaques and stable plaques between the two groups(P＜0.05).There was no significant difference in the proportion of mixed plaques(P＞0.05). Compared with the control group, the level of plasma E2 and P in ACS group and SAP group were significantly lower than those in control group(P＜0.05). Compared with the control group, the level of plasma Hcy and MPO in ACS group and SAP group were significantly higher than those in control group(P＜0.05).Compared with ACS group, the level of Hcy and MPO were significantly decreased in SAP group(P＜0.05).  Pearson correlation analysis showed that the level of serum P was positively correlated with the level of plasma Hcy(r=12.643, P=0.014), and positively correlated with the level of MPO(r=10.316, P=0.008). The level of serum E2 was negatively correlated with plasma Hcy level(r=-3.736, P=0.025) , and negatively correlated with the level of MPO(r=-6.124, P=0.017).
Conclusion The levels of serum hormones and plasma inflammatory factors in female patients with CHD before menopausal may be related to the stability of coronary plaques. Lower level of serum E2, higher level of serum P and plasma Hcy, MPO may indicate plaque vulnerability or rupture.

Key words: coronary disease, premenopause, hormones