Abstract: Objective  To investigate the current status of the adverse reactions of anti-tuberculosis treatment in patients with smear-positive pulmonary tuberculosis(SPPT) and to analyze the influencing factors.
Methods  The clinical data of 280 patients with newly-treated SPPT who were diagnosed and completed standardized treatment were analyzed retrospectively. The incidence, time and type of adverse reactions of anti-tuberculosis treatment were summarized. The influencing factors were analyzed by multivariate Logistic regression analysis.
Results  There were 67 cases of adverse reactions in 280 patients receiving anti-tuberculosis treatment, with an incidence of 23.93%; the main adverse reactions were single symptom adverse reactions, involving 60 cases(89.55%), and most of them occurred in the intensive phase of tuberculosis treatment, involving 52 cases(77.61%). Most adverse reactions were bone joint damage, liver function damage, blood system abnormality and gastrointestinal reaction. Significant differences were found in the adverse reaction group and non-adverse reaction group with respect to the age, body mass index(BMI), smoking history, drinking history and liver disease history(P＜0.05 or P＜0.01). 〖JP2〗Multivariate Logistic regression analysis showed that age>〖JP〗60 years, BMI ＜18.5, smoking history, drinking history and liver disease history were the risk factors of the adverse reactions in patients with newly-treated SPPT during anti-tuberculosis treatment(P＜0.05 or P＜0.01).
Conclusion  The main adverse reactions were single symptom adverse reactions in patients with newly-treated SPPT during the anti-tuberculosis treatment, and most of them occurred in intensive phase of tuberculosis treatment, mainly involving the bone joint damage, liver function damage, blood system abnormality and gastrointestinal reaction. Close attention should be paid to patients with newly-treated SPPT who were aged >60 years, and had BMI ＜18.5, smoking history, drinking history and liver disease history in the regular anti-tuberculosis treatment, and the occurrence of treatment-related adverse reactions should be reduced or prevented, thereby improving the treatment compliance and the cure rate.

Key words: tuberculosis, pulmonary, anti-tuberculosis treatment, drug toxicity, influencing factor analysis〖