Abstract: Objective  To investigate the relationship between type I collagen carboxy terminal peptide β special sequence(β-CTX), uric acid(UA), fibroblast growth factor 23(FGF-23) and mineral bone abnormalities in patients with chronic renal failure(CRF) undergoing hemodialysis.
Methods  A total of 80 patients with CRF undergoing hemodialysis in our hospital were included in the study, and the retrospective analysis was carried out. The general data of the patients were collected, including age, body mass index, primary disease, usage of phosphate bond, dialysis duration and laboratory indexes such as β-CTX, UA, FGF-23, etc., and the incidence of mineral bone abnormality was investigated. Multivariate Logistic regression analysis was used to analyze the independent influencing factors of mineral bone abnormality in CRF patients undergoing hemodialysis, and the relationship between β-CTX, UA, FGF-23 and mineral bone abnormality in CRF patients undergoing hemodialysis was analyzed.
Results  Among 80 patients with CRF undergoing hemodialysis, there were 44 cases with mineral bone abnormality, which were set as mineral bone abnormality group, and 36 cases with non-mineral bone abnormality, which were set as non-mineral bone abnormality group. The age, dialysis duration, serum albumin(SA), UA, FGF-23 in the mineral bone abnormality group were significantly higher than those in the non-mineral bone abnormality group（P＜0.05）, and the β-CTX was significantly lower than that in the non-mineral bone abnormality group（P＜0.05）. Multivariate Logistic regression analysis showed that age（OR=1.364，P=0.034）, dialysis duration （OR=1.534，P＜0.001）, UA（OR=1.502，P=0.165）, β-CTX（OR=1.486，P＜0.001）and FGF-23（OR=1.385，P=0.001） were the independent influencing factors of mineral bone abnormality in CRF patients undergoing hemodialysis（P＜0.05）. 
Conclusion  Age, dialysis duration, UA, β-CTX and FGF-23 are independent influencing factors of mineral bone abnormalities in patients with CRF undergoing hemodialysis, and special attention should be paid to this in clinical practice.

Key words: renal insufficiency, hemodialysis, uric acid