Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze and discuss the adverse drug reactions（ADR） in Baoding No.1 central hospital and refer to the clinical medication safety.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 479 cases of ADR reports were selected retrospectively. The patient′s gender, prognoses, route of administration, drug categories, ADR involving the organs or systems, and clinical manifestations were analyzed descriptively.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓In the 479 cases of ADR, the number of ADR caused by intravenous infusion was up to 307 cases, accounting for 64.1%. The most common cause of skin damage was 158 cases. The ADR caused by antiinfective drugs with 110 cases were the most, of which quinolones with 39 cases topped the list.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓We should strengthen and attach importance to the adverse drug reaction in order to guarantee the public to use drug safely and reasonably.

Key words: drug toxicity, data collection, analysis