Abstract: Objective  To investigate the relationship between renal blood flow indexes, inflammatory chemokines and insulin resistance of patients with hypertensive renal injury. 
Methods  A total of 80 patients with hypertensive renal injury were chosen as the observation group, and in the meantime, 80 patients with hypertension and without renal injury  were chosen as the control group. The renal blood flow indexes and inflammatory chemokines(serum CCL-2， CXCL-10 and IL-8) of two groups were detected and compared， and the renal blood flow indexes and inflammatory chemokines of observation group with different insulin resistance index were compared. The relationship between renal blood flow indexes，inflammatory chemokines and insulin resistance was analyzed with Spearman rank correlation analysis. 
Results  Peak velocity of the systolic wave(Vs) and end diastolic peak flow velocity(Vd)of the segmental renal artery and interlobar renal artery were significantly lower in the observation group than in the control group, while resistance index(RI)，pulsatility index(PI)and inflammatory chemokines of the segmental renal artery and interlobar renal artery were significantly higher than those of control group; the renal blood flow indexes and inflammatory chemokines of observation group with different insulin resistance indexes were compared，and there were statistically significant differences(P＜0.05). The Spearman rank correlation analysis showed that Vs and Vd of the segmental renal artery and interlobar renal artery were negatively correlated with insulin resistance， while the segmental renal artery and interlobar renal artery RI， PI and inflammatory chemokines were positively correlated with  insulin resistance（P＜0.05）. 
Conclusion  The renal blood flow indexes and inflammatory chemokines of patients with hypertensive renal injury are significantly abnormal， which are all closely associated with insulin resistance. Thus, detection and regulation of those indexes should warrant attention.

Key words: kidney injury, renal circulation, chemokines