Journal of Hebei Medical University ›› 2021, Vol. 42 ›› Issue (12): 1406-1410.doi: 10.3969/j.issn.1007-3205.2021.12.009

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Research on risk factors of hyperuricemia in diabetic nephropathy

  

  1. 1.Department of Nephrology, the First Central Hospital of Baoding City, Hebei Province, Baoding  
    071000, China; 2.Department of Cardiology, the First Central Hospital of Baoding City Affiliated to 
    Chengde  Medical College, Hebei Province, Baoding 071000, China; 3.Department of 
    Traditional Chinese Medicine, the First Central Hospital of Baoding City, 
    Hebei Province, Baoding 071000, China; 4.Department of  
    Endocrinology, the First Central Hospital of Baoding City, 
    Hebei Province, Baoding 071000, China
  • Online:2021-12-25 Published:2021-12-27

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Abstract: Objective  To explore the risk factors of hyperuricemia(HU) in diabetic nephropathy(DN) patients. 
Methods  In total, 350 patients with type 2 DM admitted to the First Central Hospital of Baoding City, Hebei Province, were divided into the HU group(observation group, n=150) and the normal serum uric acid group(control group, n=200). The general characteristics and clinical parameters of the two groups were compared, and the variables with statistical differences were statistically analyzed by binary Logistic regression. 
Results  The body mass index(BMI), low density lipoprotein-cholesterol(LDL-C), glycosylated hemoglobin A1c(HbA1c), 24 hour urinary protein(24 hUpro), C-reactive protein(CRP) and serum creatinine(SCr) in the observation group were higher than those in the control group(P＜0.05). The results of regression analysis showed that BMI, CRP, LDL-C and 24hUpro were independent related factors of HU in DN(P＜0.05). 
Conclusion  The independent risk factors of  HU in DN patients are BMI,CRP, LDL-C, and 24hUpro in our study.Therefore, early diagnosis and treatment-related measures should be carried out to extend the survival of patients with DN.


Key words: diabetic nephropathy, hyperuricemia, risk factors