Abstract: ObjectiveTo explore the skeletal muscle content and its influencing factors in patients with kidney disease. 
MethodsA cross-sectional study was performed to collect complete information of 91 patients with kidney disease for body composition testing. Unconditional Logistic regression analysis was performed to analyze the influencing factors of skeletal muscle in patients with kidney disease. 
ResultsSkeletal muscle content of 91 patients was （25.68 ± 6.07） kg, including 32 persons(35.2%) in the low skeletal muscle group. There were significant differences in age, creatine(Cr), blood urea nitrogen(BUN), albumin(ALB), urine protein and height between the non-low skeletal muscle group and the low skeletal muscle group(P＜0.05). There was no significant difference in gender, smoking, drinking, hypertension, diabetes, estimated glomerular filtration rate(eGFR), Cr, prealbumin(PA), triglyceride(TG) and hemoglobin(Hb)(P＞0.05). Multivariate Logistic regression analysis showed that Cr and ALB were independent risk factors for the low skeletal muscle content, while proteinuria and height were protective factors in patients with kidney disease. 
ConclusionSkeletal sarcopenia is common in kidney disease and a good indicator to assess the nutritional status of patients. The important effect of reasonable nutritional therapy on skeletal muscle should warrant attention in all stages of kidney disease.

Key words: kidney diseases, skeletal muscle, influencing factor analysis