Abstract: ObjectiveTo analyze the influencing factors of nosocomial infection in schizophrenic patients. 
MethodsA total of 3 579 inpatients with schizophrenia admitted to the Psychiatric Department of our hospital were selected retrospectively, and the incidence of nosocomial infections was recorded. The clinical baseline data, including age, sex, length of hospital stay, clinical treatment, concomitant diseases and cognitive ability, were collected, and the risk factors of nosocomial infection in schizophrenic patients were analyzed by Logistic regression analysis. 
ResultsThere were 67 cases of nosocomial infection in 3 579 patients, and the infection rate was 1.87%. There were significant differences in age, duration of schizophrenia, length of hospital stay, electroconvulsive therapy, management style, cognitive impairment, self-care and concomitant diseases between two groups(P＜0.05), while there were no statistically significant differences in gender and education level(P＞0.05). Logistic regression analysis showed that age was the protective factor for nosocomial infection in schizophrenic patients, while cognitive impairment, combined diabetes mellitus, and course of disease were risk factors for nosocomial infection in schizophrenic patients. 
ConclusionIn order to prevent nosocomial infection, the intervention should be strengthened for the elderly patients with long course of disease, cognitive impairment and schizophrenia complicated with diabetes. 

Key words: schizophrenia, cross infection, root cause analysis