Quantitative analysis of lumbar bone marrow fat content in patients with type 2 diabetes mellitus and non-diabetic patients

doi:10.3969/j.issn.1007-3205.2022.11.015

Abstract

Abstract: Objective To compare the bone marrow fat(BMF) content of lumbar spine between type 2 diabetes mellitus(T2DM) patients and non-diabetic patients.
Methods We conducted a prospective analysis of 100 patients who underwent lumbar MRI iterative decomposition of water and fat with echo asymmetry and least-squares estimation(IDEAL) sequence. The IDEAL-fat and IDEAL-water signal values of lumbar bone marrow were measured. The BMF fraction(BMFFIDEAL) was calculated. The difference of mean IDEAL-fat signal value, mean IDEAL-water signal value and the BMFFIDEAL value of lumbar bone marrow between T2DM group and non-diabetic group were compared, and their correlation with age, gender, body mass index(BMI) and glycated hemoglobin A 1c(HbAlc) were analyzed.
Results There was no significant difference in the mean IDEAL-fat signal value and mean IDEAL-water signal value of lumbar bone marrow between T2DM group and non-diabetic group(P＞0.05). The BMFFIDEAL value of lumbar bone marrow in T2DM group was higher than that in non-diabetic group(P＜0.05). There was no significant difference in the BMFFIDEAL value of lumbar bone marrow between male and female group, and between normal group and overweight group in T2DM group(P＞0.05), as well as in non-diabetic group(P＞0.05). There was no significant difference in the IDEAL-fat value among L1-L5 in both T2DM group and non-diabetic group(P＞0.05). There was significant difference in the IDEAL-water value and BMFFIDEAL value among L1-L5 in both T2DM group and non-diabetic group(P＜0.05). The BMFFIDEAL value of L1 of bone marrow was lower than that of L3 in T2DM group. The IDEAL-water value of L1 was higher than that of L3， and BMFFIDEAL value of L1 was lower than that of L3and L4 in non-diabetic group(P＜0.05). The BMFFIDEAL value of lumbar bone marrow was positively correlated with age in T2DM group and non-diabetic group. The BMFFIDEAL value of lumbar bone marrow was positively correlated with HbAlc value in T2DM group(P＜0.05).
Conclusion The BMF content of lumbar spine in T2DM patients was higher than that in non-diabetic patients, which is associated with age and HbAlc, but not related to gender and BMI.

Key words: diabetes mellitus, type 2, lumbar vertebrae, bone marrow, magnetic resonance imaging

CUI Feng-zhen, WANG Shi-lei, ZHAO Yue-qin, ZHANG Zhe, CAO Jiang-xin. Quantitative analysis of lumbar bone marrow fat content in patients with type 2 diabetes mellitus and non-diabetic patients[J]. Journal of Hebei Medical University, 2022, 43(11): 1311-1317.

[1]	JI Si-xuan, WU Di, . Diagnostic value of MSCT combined with DCE-MRI in osteosarcoma [J]. Journal of Hebei Medical University, 2023, 44(2): 199-202,223.
[2]	WU Jie, CHEN Yan, DU Xiao-xuan. Effects of intravenous anesthesia with sufentanil combined with propofolin bone marrow mesenchymal stem cell transplantation on rats with traumatic brain injury [J]. Journal of Hebei Medical University, 2021, 42(4): 454-460,465.
[3]	WANG Chun-hu, MO Nan-wen, MO Fang-liang. The effect of percutaneous transforaminal endoscopy TESSYS on structure parameters of lumbar vertebra and motor function in patients with lumbar disc herniation [J]. Journal of Hebei Medical University, 2021, 42(12): 1426-1431.
[4]	TIAN Lei, XUE Xiao-ying, WANG Yan-qiang, XIAO Zhi-qing, GE Xiao-hui. Dosimetric advantages of bonemarrow-sparing intensity modulated radiotherapy for cervical cancer after hysterectomy [J]. Journal of Hebei Medical University, 2021, 42(10): 1210-1214.
[5]	WANG Na, LIU Chang, XUE Peng, WANG Xiao, LI Yu-kun, LIU Si-jing. Effect of IRS-1/TAZ signaling on bone marrow lipogenesis and the mechanism [J]. Journal of Hebei Medical University, 2020, 41(11): 1251-1255,封三.
[6]	WANG Na, LIU Chang, LIU Si-jing, WANG Xiao, LI Yu-kun, XUE Peng. The effects of IRS-1 on osteogenic differentiation and the mechanism [J]. Journal of Hebei Medical University, 2020, 41(10): 1130-1135.
[7]	ZHANG Yanan1， CHEN Wei1， ZHANG Jinping1， QI Lili2， ZHANG Lei1， ZHAO Chunfang1*. Study on differentiation from bone marrow mesenchymal stem cells overexpressing GATA4 into cardiomyocytes [J]. Journal of Hebei Medical University, 2019, 40(8): 877-881,901.
[8]	ZHANG Yanan1， XIE Yanyan2， YIN Mingjie2， ZHANG Xiaoyi2， CHEN Wei1， ZHANG Lei1*. GATA4 gene promote 5azacytidine induced differentiation of bone marrow mesenchymal stem cells into cardiomyocytes#br# [J]. Journal of Hebei Medical University, 2019, 40(4): 385-389.
[9]	LI Zhuo， YAO liming， ZHANG Helong， JIA Chenguang， WANG Lianbo， YAO Xiaowei*. Selection of surgical methods for Brucellosis in lumbar spine and its clinical efficacy#br# [J]. Journal of Hebei Medical University, 2018, 38(8): 916-920.
[10]	NI Guangxiao1, ZHOU Guang2, SUN Weili1, MENG Ran1, FENG Yingfa3, WANG Pu4. Correlation between serum 25hydroxyvitamin D level and ankle bone marrow edema syndrome#br# [J]. Journal of Hebei Medical University, 2018, 38(11): 1334-1338.
[11]	YANG Jianbo, LI Pengfei*, JIN Xianhui, BAI Pingzhang, JIA Nan, ZHANG Qingsheng. Clinical study on the effect of different dose of ibandronate on bone healing after spinal surgery#br# [J]. Journal of Hebei Medical University, 2017, 37(4): 399-403.
[12]	NIE Zhihong;HOU Yingnuo;KONG Fanlei;ZHAO Suxiang;FAN Gelin;ZHANG Zitan. WEN Ya;ZHU Chunhua;WANG Lina;JI Hui;LIU Ying [J]. , 2014, 35(8): 889-889.

Quantitative analysis of lumbar bone marrow fat content in patients with type 2 diabetes mellitus and non-diabetic patients

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 12

Recommended Articles

Metrics

Comments