Abstract: Objective To investigate the correlation of glucagon-like peptide-1 (GLP-1) and high-sensitivity C-reactive protein in serum. hs-CRP) with metabolic syndrome (MS) and cognitive function in patients with type 2 diabetes mellitus (T2DM). 
Methods A total of 122 T2DM patients (observation group) and 61 healthy physical examinees (control group) were selected as the research subjects. The observation group was divided into MS group (T2DM combined with MS, n=81) and non-MS group (T2DM alone, n=41) according to presence of MS. According to the Montreal Cognitive Assessment Scale (MoCA), MS group was subdivided into cognitive normal group (MoCA score≥26, n=41) and cognitive dysfunction group (MoCA score ＜26, n=40). Serum GLP-1, hs-CRP, waist circumference, blood lipid and blood pressure were compared among all groups. Pearson method was used to analyze the correlation between GLP-1, hs-CRP and MS index. Binary Logistic regression model was used to analyze the effects of serum GLP-1 and hs-CRP on cognitive function in T2DM patients with MS. 
Results GLP-1, high density lipoprotein cholesterol (HDL-C) and MoCA scores in the observation group were lower than those in the control group, while hs-CRP, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), triacylglycerol (TG) and fasting blood glucose (FBG) were higher than those in control group (P＜0.05).GLP-1, HDL-C and MoCA scores in MS group were lower than those in control group, while hs-CRP, waist circumference, SBP, DBP, TG and FBG in MS group were higher than those in non-MS group (P＜0.05).The GLP-1, HDL-C and MoCA scores in the cognitive dysfunction group were lower than those in the control group, while hs-CRP, waist circum ference, SBP, DBP, TG and FBG in the cognitive dysfunction group were higher than those in the cognitive normal group (P＜0.05).Pearson correlation analysis showed that GLP-1 was negatively correlated with waist circumference, SBP, DBP and FBG, but positively correlated with HDL-C (P＜0.05). hs-CRP was positively correlated with waist circumference, SBP, DBP, TG, and FBG, and negatively correlated with HDL-C (P＜0.05).Logistic regression model analysis showed that decreased GLP-1 level and increased hs-CRP level were risk factors for cognitive dysfunction in T2DM patients with MS (P＜0.05). 
Conclusion Serum GLP-1 level is significantly decreased and hs-CRP level is significantly increased in T2DM patients with MS, and decreased serum GLP-1 level and increased hs-CRP level are risk factors for cognitive dysfunction in T2DM patients with MS. 

Key words: diabetes mellitus, type 2, metabolic syndrome, cognitive