Journal of Hebei Medical University ›› 2023, Vol. 44 ›› Issue (9): 1032-1036.doi: 10.3969/j.issn.1007-3205.2023.09.008

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Application of tranexamic acid combined with platelet-rich plasma injection under arthroscopy for the treatment of femoroacetabular impingement syndrome

  

  1. Department of Orthopedics, Cangzhou People′s Hospital, Hebei Province, Cangzhou 061000, China

  • Online:2023-09-25 Published:2023-10-12

Abstract: Objective  To explore the effect of application of tranexamic acid combined with platelet-rich plasma (PRP) injection under arthroscopy in the treatment of femoroacetabular impingement syndrome (FAIS). 
Methods  Sixty patients with FAIS who underwent arthroscopic treatment were selected as the research subjects, and then divided into an observation group (n=30) and a control group (n=30) using a random number table method. The control group was treated with PRP, while the observation group was treated with tranexamic acid combined with PRP. Intraoperative blood loss, total blood loss, length of hospital stay, and coagulation function [prothrombin time (PT), activated partial prothrombin time (APTT)] before using PRP were compared between two groups. The arthroscopic visual field visibility scale score was used to evaluate the intraoperative visual field of patients, and CT examination was performed to measure angle α and center-edge angle(CEA)of the patients. Visual analog scale (VAS), non-arthritic hip score (NAHS), and Harris hip function score (HHS) were used to assess the severity of pain and hip function of patients, and the clinical efficacy of two groups was compared. 
Results  The intraoperative blood loss, total blood loss, length of hospital stay,PT and APTT levels in the observation group were significantly lower than those in the control group, and the visual field clarity score was higher than that in the control group (P<0.05). At 12 months after surgery,angleα and CEA of the two groups were significantly lower than those before surgery (P<0.05). The VAS scores of the two groups showed a gradually decreasing trend with time, while the NAHS and HHS scores showed a gradually increasing trend. The VAS scores of the observation group were lower than those of the control group, while the NAHS and HHS scores were higher than those of the control group. There was a statistically significant difference in the interaction between groups, time points, and time points between groups (P<0.05). 
Conclusion  The application of tranexamic acid combined with PRP injection in perioperative patients with FAIS under arthroscopy can effectively improve the visual field clarity during operation, reduce blood loss, relieve pain and promote the early rehabilitation of hip joint function after operation.


Key words: femoracetabular impingement, tranexamic acid, platelet-rich plasma