河北医科大学学报

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地塞米松复合右美托咪定对臂丛神经阻滞效果的影响

  

  1. 1. 冀中能源峰峰集团总医院麻醉科,河北 邯郸 056200 ; 2. 冀中能源峰峰集团总医院输血科,河北 邯郸 056200
  • 出版日期:2016-08-25 发布日期:2016-09-01
  • 作者简介:张宁( 1981- ),男,河北邯郸人,冀中能源峰峰集团 总医院主治医师,医学硕士,从事临床麻醉学研究。

Influence of dexamethasone combined with dexmedetomidine on interscalene brachial plexus block

  1. 1. DepartmentofAnesthesiology , theGeneralHospitalAffiliatedtoJizhongEnergyFengfengConglomerate ,
    HebeiProvince , Handan 056200 , China ; 2. DepartmentofBloodTransfusion , theGeneralHospital
    AffiliatedtoJizhongEnergyFengfengConglomerate , HebeiProvince , Handan 056200 , China
  • Online:2016-08-25 Published:2016-09-01

摘要: [摘要] 目的 观察地塞米松复合右美托咪定对肌间沟臂丛神经阻滞效果的影响。方法 将在肌间沟臂丛神
经阻滞下行上肢骨折手术患者 60 例随机分为 3 组各 20 例,其中 C 组给予 0.5% 罗哌卡因, D 组给予 0.5% 罗哌卡
因 + 右美托咪定 1 μ g /
kg
, DD 组给予 0.5% 罗哌卡因 + 右美托咪定 1 μ g / kg+ 地塞米松 10mg ,药液均为 25mL 。
分别于入室时( T 0 )、手术开始时(
T 1 )、手术开始 30min 时( T 2 )和手术结束时( T 3 )记录患者心率( hearrate , HR )、
平均动脉压( meanarterialpressure , MAP )、脉搏氧饱和度(
oxygensaturation , SpO 2 )、 OAA / S 评分,并记录感觉和
运动神经阻滞起效时间、持续时间及心血管事件、过度镇静、恶心呕吐等不良反应。结果 3 组 OAA / S 评分、 HR 组
间、时点间差异有统计学意义( P <0.
05 ),而组间·时点间交互作用差异无统计学意义( P >0. 05 ); 3 组 MAP 时点
间差异有统计学意义( P <0.
05 ),而组间与组间·时点间交互作用差异无统计学意义( P >0.05 ); 3 组 SpO 2 组间、
时点间、组间·时点间交互作用差异均无统计学意义( P >0.
05 )。与 C 组比较, D 和 DD 组感觉和运动神经阻滞起
效时间缩短,持续时间延长( P <0.
05 );与 D 组比较, DD 组感觉和运动神经阻滞持续时间延长( P <0. 05 )。 DD 组
恶心呕吐发生率低于 D 组。 D 组和 DD 组少数患者出现窦性心动过缓。结论 地塞米松复合右美托咪定可以增强
罗哌卡因的镇痛效果,缩短起效时间,延长作用时间,减少不良反应,但可能诱发心动过缓。

关键词: 地塞米松, 右美托咪啶, 麻醉

Abstract: [ Abstract ] Objective To observe the effects of dexamethasone combined with
dexmedetomidineoninterscalenebrachialplexusblock.Methods Sixtypatiensscheduledfor
upperextremitysurgerywithinterscalenebrachialplexusblockwererandomlydividedintothree
groups , with20casesineachgroup.Controlgroup (
groupC ) wasgiven0.5% ropivacaine25
mL ; Dexmedetomidinegroup ( groupD ) wasreceived0.5%ropivacaine+1 μ g / kgdexmedetomidine25
mL ; dexamethasonecombinedwithdexmedetomidinegroup ( groupDD ) wasinjectedwith0. 5%
ropivacaine+1 μ g / kgdexmedetomidineanddexamethasone10 mg25 mL.Hearrate ( HR ),
meanarterialpressure ( MAP ), oxygensaturation ( SpO 2 ) and OAA / Sscoreatthetimeof
enteringtheoperatingroom ( T 0 ), beginningoftheoperation ( T 1 ), 30 minafterthestartof
operation ( T 2 ), attheendofthesurgery ( T 3 ) wereobserved.Theonsettimeanddurationof
sensoryand motorblock wererecorded.Theadverseeffectssuchasadversecardiovascular
events , excessivesedation , nauseaandvomitingwerealsorecorded.Results Thedifferencein
OAA / SscoreandHR , interblockandtimedissimilarityinthethreegroupsatthegroupsand
timepointswerestatisticallysignificant ( P <0.05 ) .However , therewasnosignificantdifference intheinteractionbetweengroupandtime ( P >0.05 ) .InOAA / SscoreandHR , interblockand
timedissimilarityofthethreegroupshadstatisticallysignificantdifference.There wasno
significantdifferenceininteractionofinterblockwithtimedissimilaritybetweenthethreegroups.
ForMAP , therewerestatisticallysignificantdifferencesintimedissimilarityamongthethree
groups ( P <0.05 ) .Therewasnosignificantdifferenceininterblockandinteractionofinterblock
withtimedissimilaritybetweenthethreegroups ( P >0.05 ) .ForSpO 2 , therewasnosignificant
differenceamongthethreegroups ( P >0.05 ) .ComparedwithgroupC , theonsettimewas ( P >
0.05 ) .ComparedwithgroupC , theonsettimewassignificantlyshortened , andthedurationof
blockwasprolonged ( P <0.05 ) ingroupDandgroupDD.ComparedwithgroupsD , theduration
ofblockwasprolongedingroupsDD ( P <0.05 ) .Theincidenceofnauseaandvomitingingroup
DDwassignificantlylowerthaningroupD.SomepatientsdevelopedbradycardiaingroupsDand
DD.Conclusion Dexamethasonecombined withdexmedetomidinecanenhancetheanalgesic
effectofropivacaine , shortentheonsettime , prolongtheactiontime , reducetheadverse
reactions , butmayinducebradycardia

Key words: dexamethasone , dexmedetomidine , anesthesia