关键词: 糖尿病, 妊娠, 性激素结合球蛋白, 生物标记

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the value of sex hormone binding globulin(SHBG) as a biomarker in prediction of gestational diabetes mellitus(GDM) at firsttrimester stage.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred and sixty cases of pregnant women during the first trimester(13-16 weeks of gestation) were enrolled in this study. The content of SHBG in the serum was measured at 13-16 weeks of gestation and followed with oral glucose tolerance test at 24-28 weeks. The results of screening of GDM showed that 21 cases in GDM group, and 239 cases in normal control group. Age, body mass index(BMI), multipara, family history of diabetes, gestational weeks, delivery, cesarean section and neonatal amniotic fluid index, body mass and SHBG content were compared in 2 groups of pregnant women.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The ratio of BMI, cesarean section and neonatal body weight in GDM group were higher than that in normal control group, while the production of gestational week, amniotic fluid index and SHBG content were lower than that of normal control group(P<0.05). ROC curve analysis(AUC=0.877, 95% CI=0.806-0.948) found that when the cutoff value of SHBG was 175.86 nmol/L, the predictive sensitivity was 90.48%, the specificity was 66.94%, the positive predictive value was 19.19%, and the negative predictive value was 98.78%.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Serum SHBG content in early pregnancy(13-16 weeks) can be used as a biomarker to predict GDM effectively.

Key words: diabetes, gestational； sex hormone binding globulin, biomarker