早期强化控压联合镇静镇痛策略对老年高血压脑出血患者血肿量及NIHSS的影响

doi:10.3969/j.issn.10073205.2018.07.010

河北医科大学学报

早期强化控压联合镇静镇痛策略对老年高血压脑出血患者血肿量及NIHSS的影响

1.邯郸钢铁集团有限责任公司职工医院神经外科，河北邯郸 056001；2.河北医科大学第二医院神经外科,
河北石家庄 050000；3.河北医科大学神经科学研究中心，河北石家庄 050017

出版日期:2018-07-25 发布日期:2018-07-04
作者简介:许光涛（1979-），男，河北唐山人，邯郸钢铁集团有限责任公司职工医院主治医师，医学硕士，从事神经外科疾病诊治研究。
基金资助:
国家重点研发计划政府间专项项目（2017YFE0110400）；邯郸市科学技术研究与发展计划（1323108148）

Effects of early intensive antihypertensive therapy joint programmed sedative analgesia treatment on elderly patients with hypertension cerebral hemorrhage hematoma size and NIHSS#br#

1.Department of Neurosurgery, Handan Steel & Iron Group Staff Hospital, Hebei Province, Handan
056001, China; 2.Department of Neurosurgery, the Second Hospital of Hebei Medical University,
Shijiazhuang, 050000, China; 3.Neuroscience Research Center, Hebei Medical
University, Shijiazhuang 050017, China

Online:2018-07-25 Published:2018-07-04

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨早期强化控压联合镇静镇痛策略对老年高血压脑出血患者血肿量及神经功能评分的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗将60例高血压脑出血非手术治疗患者随机分为2组，每组30例。对照组给予常规降压方案，控制收缩压＜160 mmHg。观察组行早期控压联合镇静镇痛治疗，控制收缩压120~140 mmHg。观察2组0 d，1 d，14 d血肿量和美国国立卫生研究院卒中量表（National Institute of Health Stroke Scale,NIHSS）评分，统计2组血肿量扩大率。
〖HTH〗结果〖HTSS〗〖KG*2〗2组血肿量和NIHSS评分比较，治疗1 d时略有增加，治疗14 d时明显减少，但观察组减少更明显，2组组间、时点间、组间·时点间交互作用差异均有统计学意义（P＜005）。2组血肿扩大率差异无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗早期控压联合镇静镇痛可有效控制血肿量增多，该方案有利于血肿清除，并有利于改善神经功能。

关键词: 颅内出血, 高血压性, 早期强化控压, 镇静镇痛

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the effect of early intensification pressure control strategy combined with sedative analgesia strategy on hematoma change and neurological function score in elderly patients with hypertensive cerebral hemorrhage.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty nonsurgical treatment patients with hypertensive intracerebral hemorrhage were randomly divided into 2 groups and 30 patients in each group. The control group was given a routine depressurization program to control systolic blood pressure < 160 mmHg. The observation group was given earlycontrolled pressure combined, and 120-140 mmHg systolic blood pressure. The hematoma volume and the NIHSS scores at 0 d, 1 d and 14 d in two groups were surveyed, and the rates of hematoma enlargement were evaluated.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The hematoma volume and the NIHSS scores of 2 groups were both increased a little at 1 d treatment, and decreased significantly at 14 d treatment, which more reduction was detected in observation group. The differences between intergroup, time point, and interaction of intergroup and time point of 2 groups all had the statistical significances(P＜005), but there were no statistical significances in hematoma enlargement rates between two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Early pressure control combined with sedative analgesia can effectively control the increase of hematoma. This therapeutic scheme is beneficial for the hematoma clearance and neurological function improvement.

Key words: intracranial hemorrhage, hypertensive； early enhancement of hypotension, sedation and analgesia

许光涛1，赵宗茂2,3*，王淑霞1，赵满意1，张征云1，卢利英1. 早期强化控压联合镇静镇痛策略对老年高血压脑出血患者血肿量及NIHSS的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.07.010.

XU Guangtao1, ZHAO Zongmao2,3*, WANG Shuxia1, ZHAO Manyi1, ZHANG Zhengyun1, LU Liying1. Effects of early intensive antihypertensive therapy joint programmed sedative analgesia treatment on elderly patients with hypertension cerebral hemorrhage hematoma size and NIHSS#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.07.010.

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早期强化控压联合镇静镇痛策略对老年高血压脑出血患者血肿量及NIHSS的影响

Effects of early intensive antihypertensive therapy joint programmed sedative analgesia treatment on elderly patients with hypertension cerebral hemorrhage hematoma size and NIHSS#br#

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