高渗盐水联合肾上腺素雾化吸入治疗重症毛细支气管炎的疗效观察

doi:10.3969/j.issn.10073205.2019.04.016

河北医科大学学报

高渗盐水联合肾上腺素雾化吸入治疗重症毛细支气管炎的疗效观察

1.河北省石家庄市妇幼保健院儿科，河北石家庄 050051；2.河北省石家庄市第三医院儿科，河北石家庄 050011

出版日期:2019-04-25 发布日期:2019-04-22
作者简介:刘连凤（1981-），女，河北曲阳人，河北省石家庄市妇幼保健院主治医师，医学硕士，从事儿科疾病诊治研究。
基金资助:
河北省医学科学研究重点课题（20150885）

Observation on the curative effect of hypertonic saline combined with adrenaline inhalation for severe capillary bronchitis#br#

1.Department of Pediatrics, the Maternal and Child Health Hospital of Shijiazhuang, Hebei Province，
Shijiazhuang 050051， China; 2.Department of Pediatrics, the Third Hospital of Shijiazhuang,
Hebei Province， Shijiazhuang 050011， China

Online:2019-04-25 Published:2019-04-22

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察高渗盐水联合肾上腺素雾化吸入治疗重症毛细支气管炎的临床疗效。
〖HTH〗方法〖HTSS〗〖KG*2〗将毛细支气管炎患儿100例依据入院顺序交替分为观察组和对照组各50例。2组均给予抗感染及对症支持治疗。观察组采用肾上腺素、3%高渗盐水联合雾化吸入治疗。对照组采用硫酸特布他林、0.9%生理盐水联合雾化吸入治疗。比较2组临床症状及体征消失时间、住院时间、临床疗效、气道炎性细胞数量变化情况及不良反应发生情况。
〖HTH〗结果〖HTSS〗〖KG*2〗观察组咳嗽、喘憋、肺部哮鸣音消失时间和住院时间均明显短于对照组（P＜0.05）；临床疗效优于对照组，总有效率明显高于对照组（P＜0.05）；气道分泌物的炎性细胞总数、淋巴细胞数、中性粒细胞数雾化吸入前后差值明显高于对照组（P＜005）。2组不良反应发生率差异无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗高渗盐水联合肾上腺素治疗重症毛细支气管炎能有效减少气道炎性细胞数，减轻气道高反应性，起效迅速，持续时间较长，疗效好，不良反应少，是治疗患儿毛细支气管炎安全、有效、经济、易于接受的疗法。

关键词: 细支气管炎, 盐水, 高渗, 肾上腺素

Abstract: ［Abstract］〓Objective〖HTSS〗〓To explore the clinical efficacy of hypertonic saline combined with adrenaline inhalation for the treatment of severe capillary bronchitis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 100 cases of children with severe capillary bronchitis were divided into observation group(n=50)and control group(n=50) , according to the order of admission. Two groups of children were both given antiinfection ,symptomatic and supportive treatment. The observation group were given epinephrine dissolved in 3% hypertonic saline for inhalation, while the control group were given terbutaline hemisulfate dissolved in 0.9% normal saline for inhalation. The clinical symptoms and signs, duration of hospitalization, clinical efficacy, changes in the number of inflammatory cells and adverse reactions were observed and compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The disappearance time of asthma suppress, cough, lung wheeze and hospital stay of the observation group were significantly shorter than those of the control group(P＜005). The total effective was higher than the control group(P＜005). The total number of inflammatory cells, lymphocytes and neutrophils in airway secretions were significantly higher than those in the control group before and after atomization inhalation (P＜005). No serious adverse reactions was happened in both groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Hypertonic saline combined with epinephrine in the treatment of severe bronchiolitis can effectively reduce the number of inflammatory cells in the airway and reduce the airway hyperresponsiveness with good effect, less adverse reactions. It is a safe, effective, economical and acceptable adjuvant therapy for the treatment of bronchiolitis in children.

Key words: bronchiolitis, saline solution, hypertonic, epinephrine

刘连凤1，史军然1，薛红霞2，李三林1，高〓虹1. 高渗盐水联合肾上腺素雾化吸入治疗重症毛细支气管炎的疗效观察[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.04.016.

LIU Lianfeng1, SHI Junran1, XUE Hongxia2, LI Sanlin1, GAO Hong1. Observation on the curative effect of hypertonic saline combined with adrenaline inhalation for severe capillary bronchitis#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.04.016.

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[15]	胡凤娥;张丽云;李红霞. 毛细支气管炎200例临床分析[J]. , 2013, 34(7): 846-846.

高渗盐水联合肾上腺素雾化吸入治疗重症毛细支气管炎的疗效观察

Observation on the curative effect of hypertonic saline combined with adrenaline inhalation for severe capillary bronchitis#br#

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