河北医科大学学报

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白内障手术灌注液中肾上腺素合理浓度的研究

  

  1. 河北省石家庄市第一医院眼科,河北 石家庄 050011
  • 出版日期:2016-07-25 发布日期:2016-08-11
  • 作者简介:赵娴( 1978- ),女,河北石家庄人,河北省石家庄市 第一医院主治医师,医学硕士,从事眼科疾病诊治研究。

Department of  Ophtholmology, the First Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050011, China

  1. Department of  Ophtholmology, the First Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050011, China
  • Online:2016-07-25 Published:2016-08-11

摘要: [摘要] 目的 观察白内障超声乳化手术灌注液中不同浓度肾上腺素的散瞳效果及对角膜内皮细胞的影响,
探讨临床应用肾上腺素的合理浓度。方法 选择单纯老年性白内障患者 105 例( 120 眼),随机分为 A 、 B 、 C3 组,每
组 40 眼, 500mL 灌注液中分别加入 0.1mL 、 0.2mL 、 0.5mL1‰ 肾上腺素注射液,均行白内障超声乳化吸除加折
叠式人工晶状体植入手术,应用非接触型角膜内皮检测仪于术前及术后 1 周检测角膜内皮细胞密度、角膜内皮六
角形细胞比例及角膜内皮细胞变异系数。结果 3 组均能使术中瞳孔直径大于或等于手术开始时水平。术前 3 组
角膜内皮细胞密度、角膜内皮六角形细胞比例、角膜内皮细胞变异系数差异无统计学意义( P >0.05 )。术后 1 周,
B
组、 C 组角膜内皮细胞密度、角膜内皮六角形细胞比例低于术前(
P <0.05 ), A 组与术前差异无统计学意义( P >
0.05 ),且 3 组间差异无统计学意义( P >0.05 )。 C 组角膜内皮细胞变异系数高于术前( P <0.05 ), A 组、 B 组角膜
内皮细胞变异系数与术前差异无统计学意义( P >0.05 ), C 组角膜内皮细胞变异系数高于 A 组(
P <0.05 )。结论
由于肾上腺素的潜在毒性作用,白内障超声乳化手术中 500mL 灌注液应加入 0.1mL1‰ 肾上腺素维持术中扩瞳。

关键词: 超声乳化白内障吸除术, 肾上腺素, 瞳孔, 内皮, 角膜

Abstract: [ Abstract ] Objective Toobservetheeffectsofdifferentconcentrationsofadrenalinin
perfusionsolutionon mydriasisandthecornealendothelium inphacoemulsificationcataract
surgeryandtodiscussclinicalrationalconcentration.Methods Onehundredandfivesimple
senilecataractpatients ( 120eyes ) weredividedrandomlyintoA , BandCgroups ( eachgroupwith
40patients ) .0.1 mL , 0.2 mLand0.5 mL1‰ adrenalin wereaddedinto500 mLperfusion
solution.Phacoemulsificationandintraocularlensimplantationwereperformedinallpatients.
Beforesurgeryand1weekaftersurgery , cornealendothelialdensity , thepercentageofhexagonal
cellsand variablecoefficient were detected by cornealendothelialcellinstrument without
touching.Results Thepupildiametersinthe3groupsduringoperationwereallgreaterthanor
equaltothoseofpreoperation.Thedifferencesofthepreoperativecornealendothelialcell
density , thepercentageofhexagonalandcellsvariablecoefficientamongthe3groupswerenot
statisticallysignificant ( P >0.05 ) .Thepostoperativecelldensityandthepercentageofhexagonal
cellswerelowerthanthosebeforeoperation.TherewassignificantdifferenceofgroupBand
groupCcomparedtothatbeforeoperationrespectively ( P <0.05 ) andthedifferenceofgroupA
wasnotstatisticallysignificant ( P >0.05 ) .Therewasnostatisticallysignificantdifferenceamong
thethreegroups ( P >0.05 ) .Thevariablecoefficientwashigherthanthatbeforeoperationin groupC ( P <0.05 ) .Therewasnostatisticallysignificantdifferenceofvariablecoefficientin
groupAandgroupBcomparedtothatbeforeoperation ( P >0.05 ) .Thevariablecoefficientof
groupCwashigherthanthatofgroupA ( P <0.05 ) .Conclusion Theeffectiveandthelowest
adrenalinconcentration ( 0.1mL1‰adrenalinin500mLperfusionsolution ) shouldbeappliedin
phacoemulsificationinconsiderationofthepotentialadrenalintoxicity.

Key words: phacoemulsification , epinephrine , pupil , endothelium, corneal