石家庄市汉族初诊桥本甲状腺炎及Graves病患儿维生素D状况比较

doi:10.3969/j.issn.10073205.2019.07.019

河北医科大学学报

石家庄市汉族初诊桥本甲状腺炎及Graves病患儿维生素D状况比较

1.河北医科大学第二医院小儿内科，河北石家庄 050000；2.河北医科大学第二医院核医学科，河北石家庄 050000

出版日期:2019-07-25 发布日期:2019-07-16
作者简介:皮亚雷(1982-)，女，河北行唐人，河北医科大学第二医院主治医师，医学硕士，从事儿童内分泌遗传代谢疾病诊治研究。
基金资助:
河北省医学科学研究重点课题（20160550）

Comparison of vitamin D status in children with newly diagnosed Hashimoto thyroiditis and Graves disease in Han nationality in Shijiazhuang City#br#

1.Department of Pediatrics, the Second Hospital of Hebei Medical University, Shijiazhuang
050000, China; 2.Department of Nuclear Medicine, the Second Hospital of Hebei
Medical University, Shijiazhuang 050000, China

Online:2019-07-25 Published:2019-07-16

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗比较桥本甲状腺炎（Hashimoto thyroiditis，HT）及Graves病（Graves disease，GD）患儿的维生素D状况，探讨维生素D在两者内在联系中的作用。
〖HTH〗方法〖HTSS〗〖KG*2〗收集石家庄市汉族初诊HT患儿40例、GD患儿37例。采集清晨空腹静脉血4 mL，测定25羟维生素D（25 hydroxyvitamin D，25OHD）、促甲状腺激素（thyrotropin,TSH）、总甲状腺素（total thyroxin,TT4）、总三碘甲腺原氨酸（total triiodothyronine,TT3）、游离甲状腺素（free thyroxine,FT4）、游离三碘甲腺原氨酸（free triiodothyronine,FT3）、促甲状腺激素受体抗体（thyrotropin receptor antibody，TRAb）、甲状腺球蛋白抗体（thyroglobulin antibody，TGAb）、过氧化物酶抗体（thyroid peroxidase antibody，TPOAb）；超声测定甲状腺左右两叶长、宽、厚度，计算甲状腺体积；电化学法测定晨起中段尿尿碘。
〖HTH〗结果〖HTSS〗〖KG*2〗HT组FT3、FT4、TT3、TT4、TRAb显著低于GD组，TSH、TGAb显著高于GD组，差异均有统计学意义（P＜005），2组25OHD、TPOAb差异均无统计学意义（P＞005）。有甲状腺体积结果的HT组TGAb显著高于GD组，TRAb显著低于GD组，差异均有统计学意义（P＜005）；2组甲状腺体积、25OHD和TPOAb差异均无统计学意义（P＞005）。有尿碘结果的HT组TGAb显著高于GD组，TRAb显著低于GD组，差异均有统计学意义（P＜005）；2组尿碘、25OHD和TPOAb差异均无统计学意义（P＞005）。HT组25OHD水平与TSH、TRAb、TGAb、TPOAb均无相关性（P＞0.05）。GD组25OHD水平与TPOAb呈弱正相关（P＜005），与TSH、TRAb、TGAb均无相关性（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗HT及GD患儿血清25OHD水平差异无统计学意义。25OHD可能不在HT与GD内在联系中发挥作用。

关键词: 桥本病, 格雷夫斯病, 维生素D

Abstract: ［Abstract］〓Objective〖HTSS〗〓To compare the vitamin D status in children with Hashimoto thyroiditis(HT) and Graves disease(GD)，and to explore the role of vitamin D in the internal relationship between the two diseases.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Forty cases with HT and 37 cases with GD were collected from Shijiazhuang Han nationality. Four milliliter fasting venous blood samples of all the patients were collected in the morning to determine 25 hydroxyvitamin D(25OHD), thyroid stimulating hormone(TSH), total thyroxine(TT4), total triiodothyronine(TT3), free thyroxine(FT4), free triiodothyronine(FT3), thyrotropin receptor antibody(TRAb), thyroid globulin antibody(TGAb) and thyroid peroxidase antibody(TPOAb). The lengths, widths and thicknesses of the left and right lobes of the thyroids were measured by ultrasound, and the thyroids volume were calculated. The iodine of the middle part urine in the morning was measured by electrochemical method.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of FT3, FT4, TT3, TT4 and TRAb in HT group were significantly lower than that of GD group, TSH and TGAb were significantly higher than those in GD group(P＜005). There were no significant differences in 25OHD and TPOAb levels between the 2 groups(P＞005). TGAb in HT group with thyroid volume was significantly higher than that in GD group, and TRAb was significantly lower than GD group(P＜005). There was no significant difference in thyroid volume, 25OHD and TPOAb between the two groups(P＞005). TGAb in HT group with the results of urine iodine was significantly higher than that in GD group, and TRAb was significantly lower than that in GD group(P＜005). There was no significant difference in urinary iodine, 25OHD and TPOAb between the two groups(P＞005). There was no correlation between 25OHD level and TSH, TRAb, TGAb, and TPOAb in HT group(P＞005). There was a weak positive correlation between 25OHD level and TPOAb in GD group(P＜005), but no correlation with TSH, TRAb and TGAb(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓There is no significant difference in serum 25OHD levels between children with HT and GD. Serum 25OHD level may not play a role in the internal relationship between the twodiseases.

Key words: Hashimoto disease, Graves disease, vitamin D

皮亚雷1，张亚男1,韩〓笑1，高丽萍2，张会丰1，阎〓雪1*. 石家庄市汉族初诊桥本甲状腺炎及Graves病患儿维生素D状况比较[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.07.019.

PI Yalei1, ZHANG Yanan1, HAN Xiao1, GAO Liping2, ZHANG Huifeng1, YAN Xue1*. Comparison of vitamin D status in children with newly diagnosed Hashimoto thyroiditis and Graves disease in Han nationality in Shijiazhuang City#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.07.019.

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石家庄市汉族初诊桥本甲状腺炎及Graves病患儿维生素D状况比较

Comparison of vitamin D status in children with newly diagnosed Hashimoto thyroiditis and Graves disease in Han nationality in Shijiazhuang City#br#

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