关键词: 脑梗死, 微RNAs, 白细胞介素类, C反应蛋白质

Abstract: ［Abstract］  ObjectiveTo investigate the correlation between serum miR215p and inflammatory cytokines interleukin6(IL6), IL8 and Creactionprotein(CRP) in patients with acute cerebral infarction(ACI). MethodsBlood samples were collected from 64 inpatients with acute cerebral infarction(duration 24-48h) and from 60 healthy physical examinees with matching age and gender as control group. Realtime quantitative PCR was performed to examine the expression profiles of serum miR215p in ischemic stroke patients and in control subjects. The ELISA method was used to detect the level of serum IL6, IL8 and CRP from two groups. Correlation analysis was made between miR215p and inflammatory factors. NIH Stroke Scale(NIHSS) scores and Activities of Daily Living(ADL) scores analysis were used to analyze the clinical prognosis of cerebral infarction patients within and after admission. ResultsThe levels of serum miR215p, IL6, IL8, CRP in the cerebral infarction group were higher than those in the control group. And miR215p were positively correlated with the expression levels of IL6, IL8 and CRP in ACI patient. After discharge, the NIHSS score of miR215p in relatively low expression group was lower than that in relatively high expression group, while the ADL score of miR215p in relatively low expression group was higher than that of miR215p in relatively high expression group. ConclusionThe upregulated miR215p expression in serum of patients with acute cerebral infarction was positively correlated with the level of serum inflammatory factors IL8, IL6 and CRP. MiR215p may serve as a potential biomarker for predicting the prognosis of patients with acute cerebral infarction.

Key words: brain infarction； micrornas, interleukins, Creactive protein